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PP1 is a potent and selective Src inhibitor for Lck/Fyn with IC50 of 5 nM/ 6 nM. PP1 inhibits whole cell tyrosine phosphorylation and proliferation in T cells stimulated with anti-CD3 and mitogens. PP1 selectively inhibits IL-2 gene expression over GM-CSF and IL-2R gene induction in human T cells.
| Molecular Weight | 281.36 |
| Formula | C16H19N5 |
| CAS Number | 172889-26-8 |
| Solubility (25°C) | DMSO 9 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Ewald Heroes, et al. The PP1 binding code: a molecular-lego strategy that governs specificity
[5] Mathieu Bollen, et al. The extended PP1 toolkit: designed to create specificity
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