About 30 results found for searched term "PAR" (0.006 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1639 | ABT-888 | PARP |
| Veliparib | ||
| ABT-888 (Veliparib) is a potent inhibitor of PARP-1 and PARP-2 with Ki values of 5.2nM and 2.9nM respectively. | ||
| M1644 | AG-014699 phosphate | PARP |
| PF-01367338, Rucaparib phosphate | ||
| AG-014699 (PF-01367338, Rucaparib) is a PARP inhibitor with a Ki of 1.4 nM. | ||
| M1664 | AZD2281 (Olaparib) | PARP |
| Olaparib; KU-0059436 | ||
| AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively. Olaparib is an autophagy and mitophagy activator. | ||
| M1680 | BKM120 (Buparlisib) | PI3K |
| NVP-BKM120; Buparlisib | ||
| BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor. | ||
| M43947 | Enoxaparine | Thrombopoietin/Thrombin |
| Enoxaparine is a low molecular heparin that binds to antithrombin (AT) and accelerates its inhibition of factor Xa.Enoxaparine has a higher affinity for factor Xa than for thrombin, and its action on thrombin does not require HCII (heparin cofactor II). | ||
| M1732 | Talazoparib | PARP |
| BMN673; LT-673; BMN-673 | ||
| Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity. | ||
| M1972 | Iniparib | PARP |
| BSI-201, NSC-746045, IND-71677 | ||
| Iniparib is an irreversible, noncompetitive inhibitor of PARP1 that disrupts binding between PARP1 and DNA by interacting with the DNA binding domain. | ||
| M2215 | Niraparib (MK-4827) | PARP |
| MK-4827 | ||
| MK-4827 (Niraparib) is a selective PARP1/2 inhibitor with an IC50 value of 3.8 nM/2.1 nM that increases the formation of PARP-DNA complexes through inhibition of PARPase activity, leading to DNA damage, apoptosis, PARP-1-dependent cell death (parthanatos) and cell death. Strong effector activity when acting on cancer cells harboring mutant BRCA-1 and BRCA-2. It is more than 330-fold more selective than PARP3, V-PARP and Tank1. | ||
| M2288 | Carboplatin | DNA/RNA Synthesis |
| NSC 241240; Paraplatin | ||
| Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. | ||
| M2574 | ML161 | PAR |
| Parmodulin 2 | ||
| Parmodulin 2 (ML161) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM. | ||
| M2701 | Fidaxomicin | Antibiotic |
| OPT-80; PAR-101; Clostomicin B1; Tiacumicin B | ||
| Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit. | ||
| M2884 | NMDA | GluR |
| N-Methyl-D-aspartic acid | ||
| NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. | ||
| M2914 | Paromomycin Sulfate | Antibiotic |
| Aminosidine sulfate; Paromomycin sulfate salt | ||
| Paromomycin Sulfate is an aminoglycoside antibioticis inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA. | ||
| M3301 | Acetaminophen | Animal Modeling |
| APAP; Paracetamol; Tylenol; 4-Acetamidophenol | ||
| Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M3928 | Scoparone | STAT |
| 6,7-Dimethoxycoumarin | ||
| Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. | ||
| M3930 | Parthenolide | NF-κB |
| (-)-Parthenolide | ||
| Parthenolide (PTL) is a sesquiterpene lactone isolated from feverfew and exhibits potent antitumor activity against various cancers. | ||
| M1588 | Duloxetine Phenolic Impurity | Metabolite/Endogenous Metabolite |
| Para-Naphthol duloxetine | ||
| Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI). | ||
| M4323 | Physcion | Antibiotic |
| Rheochrysidin; Parietin | ||
| Physcion is an anthraquinone from roots of Rheum officinale Baill. | ||
| M4364 | Paris saponin VII | Akt |
| Chonglou Saponin VII | ||
| Paris saponin VII (Chonglou Saponin VII) is a steroid saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. | ||
| M4565 | (-)-Sparteine-sulfate-pentahydrate | Others |
| (-)-Sparteine-sulfate-pentahydrate | ||
| M4816 | Paricalcitol | Vitamin |
| Paricalcitol, an analog of 1,25-dihydroxyvitamin D3 with lower calcemic activity, against uterine fibroids using in vitro and in vivo evaluations in appropriate uterine fibroid cells and animal models. | ||
| M4854 | BMN-673 8R,9S | PARP |
| Talazoparib (8R,9S); (8R,9S)-LT-673 | ||
| BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673.BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2. | ||
| M4887 | Pardoprunox Hydrochloride | 5-HT Receptor |
| SLV-308 | ||
| Pardoprunox hydrochloride (DU-126891, SME-308) is an effective agonist of partial dopamine action, corresponding to pEC50 value 8.0. It is also a partial agonist inducing [35S]GTPγS binding, corresponding to pEC50 9.2 and serotonin 5-HT1A receptor 6.3. | ||
| M4931 | Rucaparib | PARP |
| AG014699; PF-01367338 | ||
| Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. | ||
| M5011 | Propargyl Methacrylate | Others |
| M5160 | Reparixin | CXCR |
| Repertaxin; DF 1681Y | ||
| Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors with IC50 of 1 and 100 nM, respectively. | ||
| M5267 | E7449 | PARP |
| Stenoparib; 2X-121; MGI25036 | ||
| E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. | ||
| M5367 | 4-Aminobenzoic acid | Others |
| para-Aminobenzoic acid | ||
| 4-Aminobenzoic acid is an intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi. | ||
| M5425 | Aspartame | Others |
| SC-18862 | ||
| Aspartame is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. | ||
| M5630 | Ethylparaben | Antibiotic |
| Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate | ||
| Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. | ||
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