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 About 30 results found for searched term "MI-3" (0.007 seconds)

Cat.No.  Name Target
M1686 Bortezomib (PS-341) Proteasome
Velcade; PS-341; LDP 341; MG 341; NSC 681239
Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM.
M1763 Mirdametinib (PD0325901) MEK
Mirdametinib;PD325901
Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM.
M1839 MDV3100 Androgen Receptor
Enzalutamide; MDV-3100
MDV3100 is an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity.
M1962 Lenalidomide TNF Receptor
Revlimid, CC-5013
Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties.
M2174 Calcitriol Estrogen Receptor
1,25-Dihydroxyvitamin D3
Calcitriol is an Active metabolite of vitamin D3 that activates the vitamin D receptor. *The compound is unstable in solutions, freshly prepared is recommended
M2278 Bosentan Hydrate Endothelin Receptor
Benzenesulfonamide Hydrate; Ro-47-0203 Hydrate
Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.
M2297 Devimistat (CPI-613) Dehydrogenase
Devimistat
Devimistat (CPI-613) inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase.
M2381 AMD3465 hexahydrobromide (AMD3465 ) CXCR
GENZ-644494 hexahydrobromide
AMD3465 hexahydrobromide(AMD3465 ) is an effective CXCR4 antagonist that inhibits 12G5 mAb in SupT1 cells. The IC50 values of CXCL12AF647 and CXCR4 were 0.75 nM and 18 nM, respectively. AMD 3465 also effectively inhibited X4 HIV replication (IC50, 1-10 nM), but not R5 HIV replication.
M2467 Bosentan Endothelin Receptor
Benzenesulfonamide; Ro-47-0203
Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.
M2565 PR-619 Deubiquitinase
2,6-Diamino-3,5-dithiocyanopyridine
PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis.
M2901 Otilonium Bromide AChR/AChE
Octylonium bromide; SP63
Otilonium bromide is an antimuscarinic.
M2963 Proflavine Hemisulfate Antibiotic
Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate
Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
M3254 Pyrimethamine Antifolate
Pirimecidan; Pirimetamin; RP 4753
Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM.
M3708 Anastrozole Cytochrome P450 (e.g. CYP17)
Arimidex, ZD1033
Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis.
M1545 Infliximab TNF Receptor
Remicade; Avakine; CT-P13
Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that blocks TNF-α interaction with TNF-α receptor 1 (TNFR1) and TNFR2. For the treatment of autoimmune diseases. Infliximab is available in BALB/ C or C57/Bl6 mice.
M4251 Schisanhenol Others
Schizanhenol; Gomisin-K3
Schisanhenol is a natural compound that has been reported as an inhibitor of UGT2B7.
M4271 Delavinone Others
Sinpeimine; CAS# 103530-47-8
Delavinone
M4448 Acetylcimigenol-3-O-α-L-arabinopyranside Others
Acetylshengmanol -3-O-α -L-arabinose is an extract of cohosh.
M4449 Cimigenol-3-O-α-L-arabinoside AMPK
Cimicifugoside M
Cimiracemoside C, the active ingredient in cohosh, activates AMPK and has anti-diabetes potential.
M4554 cyanidin-3-O-glucoside Others
Chrysontemin; Cyanidin 3-O-glucoside chloride
Kuromanin 3-O-glucoside (Kuromanin chloride), derived from mulberry leaves, has the effect of increasing blood glucose concentration and maintaining lipid metabolism balance to reduce obesity.
M4675 Cimigenol-3-O-β-D-xylpyranoside Others
Cimigenoside is an active component of the genus Cohosh.
M4817 Tacalcitol Vitamin
1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3
Tacalcitol is a synthetic vitamin D3 analog.
M4896 Nicotinamide Sirtuin
Vitamin B3; Nicotinic acid amide; Niacinamide
Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions.
M4907 Doxycycline Hyclate MMP
Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031
Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections.
M5515 Cholecalciferol Vitamin
Vitamin D3; Colecalciferol
Vitamin D3 (Cholecalciferol) is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM. *The compound is unstable in solutions, freshly prepared is recommended
M5225 MI-773 Mdm2
MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.
M5295 MI-538 Epigenetic Reader Domain
Mi-538 is an inhibitor of the interaction between MENin and MLL fusion protein with an IC50 value of 21 nM.
M5394 Alfacalcidol Vitamin
1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3
Alfacalcidol is a non-selective VDR activator medication.
M5461 Bisoctrizole Others
Tinosorb M, Tinuvin-360, UV-360, Milestab-360
Bisoctrizole is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. Also a hybrid UV absorber, reflecting and scattering UV.
M5479 Carsalam Others
Carbonylsalicylamide; 2H-1,3-Benzoxazine-2,4(3H)-dione
Carsalam (Carbonylsalicylamide) is a non-steroidal anti-inflammatory compound.



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