About 30 results found for searched term "MI-3" (0.007 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1686 | Bortezomib (PS-341) | Proteasome |
| Velcade; PS-341; LDP 341; MG 341; NSC 681239 | ||
| Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. | ||
| M1763 | Mirdametinib (PD0325901) | MEK |
| Mirdametinib；PD325901 | ||
| Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM. | ||
| M1839 | MDV3100 | Androgen Receptor |
| Enzalutamide; MDV-3100 | ||
| MDV3100 is an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. | ||
| M1962 | Lenalidomide | TNF Receptor |
| Revlimid, CC-5013 | ||
| Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. | ||
| M2174 | Calcitriol | Estrogen Receptor |
| 1,25-Dihydroxyvitamin D3 | ||
| Calcitriol is an Active metabolite of vitamin D3 that activates the vitamin D receptor. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M2217 | Mitoxantrone dihydrochloride | Topoisomerase |
| Mitozantrone dihydrochloride; NSC 301739 dihydrochloride | ||
| Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. | ||
| M2278 | Bosentan Hydrate | Endothelin Receptor |
| Benzenesulfonamide Hydrate; Ro-47-0203 Hydrate | ||
| Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M2297 | Devimistat (CPI-613) | Dehydrogenase |
| Devimistat | ||
| Devimistat (CPI-613) inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. | ||
| M2381 | AMD3465 hexahydrobromide (AMD3465 ) | CXCR |
| GENZ-644494 hexahydrobromide | ||
| AMD3465 hexahydrobromide（AMD3465 ) is an effective CXCR4 antagonist that inhibits 12G5 mAb in SupT1 cells. The IC50 values of CXCL12AF647 and CXCR4 were 0.75 nM and 18 nM, respectively. AMD 3465 also effectively inhibited X4 HIV replication (IC50, 1-10 nM), but not R5 HIV replication. | ||
| M2467 | Bosentan | Endothelin Receptor |
| Benzenesulfonamide; Ro-47-0203 | ||
| Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M2565 | PR-619 | Deubiquitinase |
| 2,6-Diamino-3,5-dithiocyanopyridine | ||
| PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis. | ||
| M2753 | Hemicholinium 3 | AChR/AChE |
| Hemicholinium dibromide; HC-3 | ||
| Hemicholinium 3 is a compound which blocks the reuptake of choline by the high-affinity choline transporter (ChT) at the presynapse. Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. | ||
| M2901 | Otilonium Bromide | AChR/AChE |
| Octylonium bromide; SP63 | ||
| Otilonium bromide is an antimuscarinic. | ||
| M55629 | MIPS-21335 | PI3K |
| MIPS21335 | ||
| MIPS-21335 is a PI3KC2α inhibitor, with IC50 of 7 nM. MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ with IC50 values of 0.043, 0.140, 0.386, 0.742 μM, respectively. | ||
| M2963 | Proflavine Hemisulfate | Antibiotic |
| Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate | ||
| Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. | ||
| M3118 | Verapamil hydrochloride | Calcium Channel |
| (±)-Verapamil hydrochlorid; CP-16533-1 hydrochloride | ||
| Verapamil hydrochloride (VPH) is an orally active L-type calcium channel inhibitor that eliminates calcium channel agonist-induced calcium inward flow and apoptosis. Verapamil hydrochloride is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. | ||
| M3254 | Pyrimethamine | Antifolate |
| Pirimecidan; Pirimetamin; RP 4753 | ||
| Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. | ||
| M3493 | Mitoxantrone | Topoisomerase |
| Mitozantrone; NSC 301739 | ||
| Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively | ||
| M3605 | Salbutamol hemisulfate | Adrenergic Receptor |
| Albuterol hemisulfate; AH-3365 hemisulfate | ||
| Salbutamol hemisulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM. | ||
| M3708 | Anastrozole | Cytochrome P450 (e.g. CYP17) |
| Arimidex, ZD1033 | ||
| Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. | ||
| M1545 | Infliximab | TNF Receptor |
| Remicade; Avakine; CT-P13 | ||
| Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that blocks TNF-α interaction with TNF-α receptor 1 (TNFR1) and TNFR2. For the treatment of autoimmune diseases. Infliximab is available in BALB/ C or C57/Bl6 mice. | ||
| M4251 | Schisanhenol | Others |
| Schizanhenol; Gomisin-K3 | ||
| Schisanhenol is a natural compound that has been reported as an inhibitor of UGT2B7. | ||
| M4271 | Delavinone | Others |
| Sinpeimine; CAS# 103530-47-8 | ||
| Delavinone | ||
| M4448 | Acetylcimigenol-3-O-α-L-arabinopyranside | Others |
| Acetylshengmanol -3-O-α -L-arabinose is an extract of cohosh. | ||
| M4449 | Cimigenol-3-O-α-L-arabinoside | AMPK |
| Cimicifugoside M | ||
| Cimiracemoside C, the active ingredient in cohosh, activates AMPK and has anti-diabetes potential. | ||
| M4554 | Cyanidin-3-O-glucoside | Others |
| Chrysontemin; Cyanidin 3-O-glucoside chloride | ||
| Kuromanin 3-O-glucoside (Kuromanin chloride), derived from mulberry leaves, has the effect of increasing blood glucose concentration and maintaining lipid metabolism balance to reduce obesity. | ||
| M4675 | Cimigenol-3-O-β-D-xylpyranoside | Others |
| Cimigenoside is an active component of the genus Cohosh. | ||
| M4817 | Tacalcitol | Vitamin |
| 1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3 | ||
| Tacalcitol is a synthetic vitamin D3 analog. | ||
| M4896 | Nicotinamide | Sirtuin |
| Vitamin B3; Nicotinic acid amide; Niacinamide | ||
| Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. | ||
| M4907 | Doxycycline Hyclate | MMP |
| Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031 | ||
| Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. | ||
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