About 29 results found for searched term "LYP-IN-3" (0.148 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42537 | LYP-IN-3 | Phosphatase |
| LYP-IN-3 is a selective inhibitor of Lymphoid-tyrosine phosphatase (LYP) (Ki=0.93 μM), and regulates T-cell receptor (TCR) signaling pathway in tumor progress. | ||
| M25536 | Recombinant Human CXCL13/BCA-1 (E. coli) | Cytokines and Growth Factors |
| CXC chemokine BLC; Small-inducible cytokine B13 | ||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | ||
| M4062 | Punicalagin | Anti-infection |
| Punicalagin is a species from Punica Granatum L. Or polyphenols isolated from the leaves of Terminalia catappa L. Punicalagin is a reversible, noncompetitive 3CLpro inhibitor that inhibits SARS-COV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) drug with antioxidant, anti-inflammatory and anticancer effects. Punicalagin has the potential to be used in COVID-19 research. | ||
| M4179 | Neochlorogenic-acid | NF-κB |
| trans-5-O-Caffeoylquinic acid | ||
| Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid can inhibit the production of TNF-α and IL-1β. Neochlorogenic acid inhibited the expression of iNOS and COX-2 proteins. Neochlorogenic acid also inhibited the activation of phosphorylated NF-κB P65 and P38 MAPK. | ||
| M4208 | (-)-Epigallocatechin gallate | EGFR/HER2 |
| EGCG; Epigallocatechol Gallate | ||
| (-)-Epigallocatechin Gallate is an antioxidant polyphenol flavonoid form green tea, and inhibits the activation of EGFR, HER2 and HER3, with antitumor activity. | ||
| M4363 | Polyphyllin-VI | Pyroptosis |
| Polyphyllin VI, an active saponin, has anticancer activity. Polyphyllin VI induces G2/M cell cycle arrest and induces apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis by inducing ROS/NF-κB/NLRP3/GSDMD signaling axis in non-small cell lung cancer. | ||
| M9708 | Chymotrypsin | Enzymes & Coenzymes |
| α-Chymotrypsin | ||
| α-Chymotrypsin is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. | ||
| M10673 | Procyanidin C1 | Apoptosis |
| PCC1 | ||
| Procyanidin C1 (PCC1) is a natural polyphenol, which causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. | ||
| M11215 | Fibrinogen (Bovine) | Others |
| Fibrinogen (Fg), i. e. coagulation factor I, molecular weight about 340kDa, by α, β, γ three pairs of different polypeptide chain. Polypeptide chains are linked by disulfide bonds. Protein Content: 67.30. | ||
| M13348 | LyP-1 TFA | Others |
| Lyp-1 TFA is a circular 9-amino acid tumor-targeting peptide that selectively binds its P32 receptor protein in a variety of tumor-associated cells. | ||
| M13447 | Recombinant Human IGF-II (E. coli) | Cytokines and Growth Factors |
| Insulin-like Growth Factor-II; Somatamedin A | ||
| Insulin-like Growth Factor II (IGF-II) is a 7 kDa single chain polypeptide with high homology to insulin. Protein structure：Expressed with an N-terminal Met. Igf-ii (ALA25-GLU91) , Accession # P01344-1. | ||
| M14930 | Disitertide diammonium | TGF-beta/Smad |
| P144 diammonium | ||
| Disitertide (P144) diammonium is a polypeptide inhibitor of transforming growth factor TGFβ1, specifically blocking its interaction with the receptor. Disitertide diammonium was also an inhibitor of PI3K and an inducer of apoptosis. | ||
| M17240 | Methyl gallate | NLR |
| Gallincin; NSC 363001; Methyl-3,4,5-trihydroxybenzoate | ||
| Methyl gallate is a polyphenol commonly found in the plant kingdom and is also an inhibitor of NLRP3, inhibiting the activation of NLRP3 inflammatory vesicles. In vitro, Methyl gallate is also a potent, highly specific inhibitor of herpes simplex virus (HSV) and has the ability to inhibit Treg cell migration. | ||
| M17933 | Pennogenin 3-O-beta-chacotrioside | Autophagy |
| Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. | ||
| M21330 | H3K4(Me3) (1-20) | Peptides |
| H3K4(Me3) (1-20), a histone polypeptide, trimethylation of histone H3 to lysine 4 (H3K4 me3) is found in active euchromatin. Sequence: Ala-Arg-Thr-{Lys(Me3)}-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu. | ||
| M28118 | Cyclotheonamide A | Serine/Threonine Protease |
| Cyclotheonamide A is a serine protease inhibitor (cyclic polypeptide), which can be obtained from marine sponges of the genus Theonella. Cyclotheonamide A shows potent inhibitory activity against trypsin (Ki=0.023 µM) and streptokinase (Ki=0.035 µM) and moderate inhibitory activity against human α-thrombin (Ki=0.18 µM). Cyclotheonamide A can be used in study of antithrombotic. | ||
| M31094 | Retatrutide acetate | Glucagon Receptor |
| LY3437943 acetate | ||
| Retatrutide (LY3437943) acetate is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide acetate inhibits for human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. | ||
| M39159 | Epitheaflagallin 3-O-gallate | MMP |
| Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits antioxidative activity, pancreatic lipase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts. | ||
| M40855 | Recombinant Human Siglec-7 Protein (HEK293, C-6His) | Receptor Proteins |
| sialic acid binding Ig-like lectin 7; CD328 antigen; p75/AIRM1; QA79 | ||
| Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. | ||
| M42544 | NC1 | Phosphatase |
| NC1 is a noncompetitive and allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor, with a Ki value 4.3 μM. | ||
| M42546 | LYP-IN-4 | Phosphatase |
| LYP-IN-4 is a reversible and selective inhibitor of lymphotyrosine phosphatase (LYP) (Ki=1.34 μM, IC50=3.52μM). | ||
| M43198 | Tri-valine | Others |
| Tri-valine (NSC 35938) is a polypeptide that can be separated from Creatine kinase, β-enolase, Triosephosphate isomerase and glyceraldehyde 3-phosphate dehydrogenase. | ||
| M49466 | Retatrutide | Glucagon Receptor |
| LY3437943 | ||
| Retatrutide is a triple agonist peptide for glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) that binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively. Retatrutide can be used in studies related to obesity. | ||
| M50455 | LyP-1 | Others |
| LyP-1 is a cyclic 9‐amino‐acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells. | ||
| M52697 | Aminopeptidase N Ligand (CD13) NGR peptide | Aminopeptidase |
| Aminopeptidase N Ligand (CD13) NGR peptide is a polypeptide targeting CD13 and can be used as a carrier to mediate intracellular transmission. | ||
| M53015 | Pancreatic Polypeptide, bovine | Neuropeptide Receptor |
| Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion. | ||
| M54045 | Human PD-L1 inhibitor IV | PD-1/PD-L1 |
| Human PD-L1 inhibitor IV, a polypeptide, is a competitive human PD-1 protein inhibitor with a Kd value of 1.38 μM. | ||
| M54092 | Pancreatic Polypeptide, human | Neuropeptide Receptor |
| Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist. | ||
| M58205 | DDX3-IN-1 | Anti-infection |
| DDX3 inhibitor 1 | ||
| DDX3-IN-1 is a DEAD-box polypeptide 3 (DDX3) inhibitor with CC50 values of 50 and 36 μM for HIV and HCV, respectively. DDX3-IN-1 has antiviral activity. | ||
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