Methyl gallate is a polyphenol commonly found in the plant kingdom and is also an inhibitor of NLRP3, inhibiting the activation of NLRP3 inflammatory vesicles. In vitro, Methyl gallate is also a potent, highly specific inhibitor of herpes simplex virus (HSV) and has the ability to inhibit Treg cell migration.
| Molecular Weight | 184.15 |
| Formula | C8H8O5 |
| CAS Number | 99-24-1 |
| Form | Solid |
| Solubility (25°C) | Ethanol 50 mg/mL |
| Storage | RT |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Deborah Bebout, et al. Acta Crystallogr Sect E Struct Rep Online. Methyl gallate
| Related NLR Products |
|---|
| Selnoflast
Selnoflast is an orally effective inhibitor of NLRP3 for studies related to systemic inflammation. |
| (±)11(12)-EET
(±)11(12)-EET is an NLRP3 inflammatory vesicle inhibitor that can be used in studies related to anti-inflammation, neovascularization, and cardioprotection. |
| Antcin A
Antcin A is an NLRP3 inhibitor that inhibits the assembly and activation of NLRP3 inflammatory vesicles. In addition, Antcin A inhibits pyroptosis of Kupffer cells and has hepatoprotective activity.Antcin A can be used in inflammation-related studies. |
| ADS032
ADS032 is a dual inhibitor of NLRP1 and NLRP3 that rapidly, reversibly and stably inhibits inflammasome formation and reduces NLPR1 and NLRP3 activation of human-derived macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduces NLRP3-induced ASC speck formation. In addition, ADS032 protects mice from the deadly influenza A virus, reduces lung inflammation and improves survival. |
| Emlenoflast sodium
Emlenoflast sodium is a sulfonylurea and a potent and selective inhibitor of NLRP3 inflammatory vesicles with an IC50 value of less than 100 nM.Emlenoflast sodium can be used in the study of inflammatory diseases. |
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