About 20 results found for searched term "H-89" (0.051 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1729 | H-89 Dihydrochloride | PKA |
| H-89 2HCl | ||
| H-89 dihydrochloride is a selective inhibitor of protein kinase A (PKA) with an IC50 value of 135 nM. | ||
| M1748 | LBH589 (Panobinostat) | HDAC |
| NVP-LBH589, Panobinostat | ||
| LBH589 (Panobinostat) is a novel broad-spectrum HDAC inhibitor for MOLT-4 and Reh cells with IC50 of 5 and 20 nM, respectively. | ||
| M2076 | SP600125 | JNK |
| JNK Inhibitor II; 1PMV; NSC75890; Pyrazolanthrone | ||
| SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM. | ||
| M3250 | Vanoxerine dihydrochloride | Dopamine Receptor |
| GBR-12909 dihydrochloride; I893 dihydrochloride | ||
| Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). | ||
| M3352 | Lamivudine (BCH-189) | Reverse Transcriptase |
| BCH-189 | ||
| Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) with an IC50 of 2.7 mM. Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS. | ||
| M3559 | H-89 | PKA |
| Protein kinase inhibitor H-89 | ||
| H-89 is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. | ||
| M6283 | SCH 900776 (CAS:891494-64-7) | CDK |
| MK-8776 | ||
| MK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. | ||
| M6336 | 3-Deazaneplanocin A hydrochloride | Histone Methyltransferase |
| DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride | ||
| 3-Deazaneplanocin A hydrochloride（DZNep HCl） is a eZH2 histone methyltransferase inhibitor. | ||
| M9756 | Pocapavir | Anti-infection |
| SCH-48973; V-073 | ||
| Pocapavir(also known as SCH-48973 and V-073) is a potent, selective antienterovirus compound. | ||
| M10514 | Verdiperstat (AZD3241) | Others |
| AZD3241; BHV-3241; CAS#890655-80-8 | ||
| Verdiperstat (AZD-3241) is a selective and irreversible inhibitor of myeloperoxidase (MPO) with an IC50 of 630 nM. | ||
| M10606 | Radiprodil (RGH-896) | NMDA |
| RGH-896 | ||
| Radiprodil (also known as RGH-896) is an orally active and selective NMDA receptors antagonist which was evaluated as potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). | ||
| M10887 | SHP389 | Others |
| SHP389 is an allosteric inhibitor of SHP2, which is anti-SHP2 and p-ERK IC50 The values are all 36 nM. | ||
| M11277 | IDH889 | Isocitrate Dehydrogenase (IDH) |
| IDH889 is an orally available, brain permeable, allosteric and mutation-specific inhibitor of isocitrate dehydrogenase (IDH1). IDH889 showed high selectivity against IDH1R132 * mutant, with IC50 values of 0.02 μM, 0.072 μM and 1.38 μM against IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 showed high inhibition of intracellular 2-Hg level with IC50 value of 0.014 μM. | ||
| M13383 | (Rac)-Indoximod | IDO |
| 1-Methyl-DL-tryptophan; (Rac)-NLG-8189 | ||
| (Rac)-Indoximod(1-methyl-DL-tryptophan) is an indoleamine 2, 3-dioxygenase (IDO) inhibitor. | ||
| M13995 | Adriforant hydrochloride | Histamine Receptor |
| PF-3893787 hydrochloride; ZPL-3893787 hydrochloride | ||
| Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (Ki=2.4 nM) and is also a functional (Ki=1.56 nM) antagonist. | ||
| M21696 | Batiraxcept | TAM Receptor |
| AVB-S6-500; DHG78903 | ||
| Batiraxcept (AVB-S6-500) is a highly potent and specific GAS6-AXL signaling pathway inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro. | ||
| M24569 | Oxelumab | IL Receptor/Related |
| R 4930; huMAb OX 40L; Ro 49-89991 | ||
| Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma. | ||
| M28434 | 5'-Amino-5'-deoxyadenosine | Nucleoside Antimetabolite/Analog |
| NH2dAdo; Nsc 238990 | ||
| 5'-Amino-5'-deoxyadenosine (NH2dAdo; Nsc 238990) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | ||
| M41574 | YCH1899 | PARP |
| YCH1899 is an orally active PARP inhibitor, with an IC50< 0.001 nM for PARP1/2. | ||
| M54530 | (1R)-IDH889 | Isocitrate Dehydrogenase (IDH) |
| (1R)-IDH889 is the inactive isomer of IDH889, which serves as a control compound in experiments.IDH889 is an orally active, brain-permeable, variant- and mutation-specific inhibitor of isocitrate dehydrogenase (IDH1).IDH889 is highly selective for the IDH1 R132 mutant, and acts efficiently on IDH1R132H, IDH1R132C and IDH1wt with IC50 values of 0.02 μM, 0.072 μM and 1.38 μM, respectively.In addition, IDH889 has a potent and potent effect on IDH1R132C and IDH1wt, IDH889 is highly selective for the IDH1 R132 mutant, with IC50 values of 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt, respectively, and has a high potency to inhibit the level of intracellular 2-HG, with an IC50 value of 0.014 μM. | ||
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