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 About 20 results found for searched term "H-89" (0.053 seconds)

Cat.No.  Name Target
M1729 H-89 Dihydrochloride PKA
H-89 2HCl
H-89 dihydrochloride is a selective inhibitor of protein kinase A (PKA) with an IC50 value of 135 nM.
M1748 LBH589 (Panobinostat) HDAC
NVP-LBH589, Panobinostat
LBH589 (Panobinostat) is a novel broad-spectrum HDAC inhibitor for MOLT-4 and Reh cells with IC50 of 5 and 20 nM, respectively.
M2076 SP600125 JNK
JNK Inhibitor II; 1PMV; NSC75890; Pyrazolanthrone
SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM.
M3250 Vanoxerine dihydrochloride Dopamine Receptor
GBR-12909 dihydrochloride; I893 dihydrochloride
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent and selective dopamine receptor inhibitor.
M3352 Lamivudine (BCH-189) Reverse Transcriptase
BCH-189
Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) with an IC50 of 2.7 mM. Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS.
M3559 H-89 PKA
Protein kinase inhibitor H-89
H-89 is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II.
M6283 SCH 900776 (CAS:891494-64-7) CDK
MK-8776
MK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2.
M6336 3-Deazaneplanocin A hydrochloride Histone Methyltransferase
DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride
3-Deazaneplanocin A hydrochloride(DZNep HCl) is a eZH2 histone methyltransferase inhibitor.
M9756 Pocapavir Anti-infection
SCH-48973; V-073
Pocapavir(also known as SCH-48973 and V-073) is a potent, selective antienterovirus compound.
M10514 Verdiperstat (AZD3241) Others
AZD3241; BHV-3241; CAS#890655-80-8
Verdiperstat (AZD-3241) is a selective and irreversible inhibitor of myeloperoxidase (MPO) with an IC50 of 630 nM.
M10606 Radiprodil (RGH-896) NMDA
RGH-896
Radiprodil (also known as RGH-896) is an orally active and selective NMDA receptors antagonist which was evaluated as potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).
M10887 SHP389 Others
SHP389 is an allosteric inhibitor of SHP2, which is anti-SHP2 and p-ERK IC50 The values are all 36 nM.
M11277 IDH889 Isocitrate Dehydrogenase (IDH)
IDH889 is an orally available, brain permeable, allosteric and mutation-specific inhibitor of isocitrate dehydrogenase (IDH1). IDH889 showed high selectivity against IDH1R132 * mutant, with IC50 values of 0.02 μM, 0.072 μM and 1.38 μM against IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 showed high inhibition of intracellular 2-Hg level with IC50 value of 0.014 μM.
M13383 (Rac)-Indoximod IDO
1-Methyl-DL-tryptophan; (Rac)-NLG-8189
(Rac)-Indoximod(1-methyl-DL-tryptophan) is an indoleamine 2, 3-dioxygenase (IDO) inhibitor.
M13995 Adriforant hydrochloride Histamine Receptor
PF-3893787 hydrochloride; ZPL-3893787 hydrochloride
Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (Ki=2.4 nM) and is also a functional (Ki=1.56 nM) antagonist.
M21696 Batiraxcept TAM Receptor
AVB-S6-500; DHG78903
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro.
M24569 Oxelumab IL Receptor/Related
R 4930; huMAb OX 40L; Ro 49-89991
Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma.
M28434 5'-Amino-5'-deoxyadenosine Nucleoside Antimetabolite/Analog
NH2dAdo; Nsc 238990
5'-Amino-5'-deoxyadenosine (NH2dAdo; Nsc 238990) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
M41574 YCH1899 PARP
YCH1899 is an orally active PARP inhibitor, with an IC50< 0.001 nM for PARP1/2.
M54530 (1R)-IDH889 Isocitrate Dehydrogenase (IDH)
(1R)-IDH889 is the inactive isomer of IDH889, which serves as a control compound in experiments.IDH889 is an orally active, brain-permeable, variant- and mutation-specific inhibitor of isocitrate dehydrogenase (IDH1).IDH889 is highly selective for the IDH1 R132 mutant, and acts efficiently on IDH1R132H, IDH1R132C and IDH1wt with IC50 values of 0.02 μM, 0.072 μM and 1.38 μM, respectively.In addition, IDH889 has a potent and potent effect on IDH1R132C and IDH1wt, IDH889 is highly selective for the IDH1 R132 mutant, with IC50 values of 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt, respectively, and has a high potency to inhibit the level of intracellular 2-HG, with an IC50 value of 0.014 μM.



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