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5'-Amino-5'-deoxyadenosine

Cat. No. M28434

All AbMole products are for research use only, cannot be used for human consumption.

5'-Amino-5'-deoxyadenosine Structure
Synonym:

NH2dAdo; Nsc 238990

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Quality Control & Documentation
Biological Activity

5'-Amino-5'-deoxyadenosine (NH2dAdo; Nsc 238990) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

Chemical Information
Molecular Weight 266.26
Formula C10H14N6O3
CAS Number 14365-44-7
Form Solid
Solubility (25°C) DMSO 200 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ildikó Stier, et al. PLoS One. Cytosine-to-uracil deamination by SssI DNA methyltransferase

[2] Matt A Peterson, et al. Nucleosides Nucleotides Nucleic Acids. Antiproliferative and protein kinase binding activities of Some N6, 5'-bis-ureido 5'-amino-5'-deoxyadenosine derivatives

[3] Vida Zohrabi-Kalantari, et al. Mol Divers. Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines

[4] B Grytzmann, et al. Chemotherapy. Derivatives of 3'- and 5'-deoxyadenosine: their inhibitory activity against DNA viruses

[5] D B Trowbridge, et al. J Am Chem Soc. Ring openings of trimetaphosphoric acid and its bismethylene analog. Syntheses of Adenosine 5'-bis(dihydroxyphosphinylmethyl)phosphinate and 5'-amino-5'-deoxyadenosine 5'-triphosphate

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  Catalog
Abmole Inhibitor Catalog




Keywords: 5'-Amino-5'-deoxyadenosine, NH2dAdo; Nsc 238990 supplier, Nucleoside Antimetabolite/Analog, inhibitors, activators

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