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5-Cyanouridine

Cat. No. M41564
5-Cyanouridine Structure
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Biological Activity

5-Cyanouridine is a thymidine analog.

Chemical Information
Molecular Weight 269.21
Formula C10H11N3O6
CAS Number 4425-57-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Song Mao et al. Curr Protoc Nucleic Acid Chem. Synthesis of 5-Cyanomethyluridine (cnm5 U) and 5-Cyanouridine (cn5 U) Phosphoramidites and Their Incorporation into RNA Oligonucleotides

[2] Song Mao et al. Chembiochem. Cyano Modification on Uridine Decreases Base-Pairing Stability and Specificity through Neighboring Disruption in RNA Duplex

[3] Maria Elena Meza-Avina et al. Bioorg Med Chem. Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase

[4] A Vachálková et al. Neoplasma. Some electrochemical characteristics of synthetic analogs of nucleic acid components. IV. 5-Cyano-, 5-carboxy- and 5-azaderivatives, and the effect of this substitution on potential carcinogenicity

[5] P F Torrence et al. J Med Chem. Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine

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Keywords: 5-Cyanouridine supplier, Nucleoside Antimetabolite/Analog, inhibitors, activators

 
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