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Verdiperstat (AZD3241)

Cat. No. M10514
Verdiperstat (AZD3241) Structure
Synonym:

AZD3241; BHV-3241; CAS#890655-80-8

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 150  USD150 In stock
50mg USD 430  USD430 In stock
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Quality Control & Documentation
Biological Activity

Verdiperstat (AZD-3241) is a selective and irreversible inhibitor of myeloperoxidase (MPO) with an IC50 of 630 nM. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation.

Chemical Information
Molecular Weight 253.32
Formula C11H15N3O2S
CAS Number 890655-80-8
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Aurelija Jucaite, et al. Brain. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease

[2] Peter Johnstrom, et al. Nucl Med Biol. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing

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Keywords: Verdiperstat (AZD3241), AZD3241; BHV-3241; CAS#890655-80-8 supplier, inhibitors, activators


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