About 30 results found for searched term "GALA" (0.019 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2147 | Ilomastat | MMP |
| GM6001; Galardin | ||
| Ilomastat (GM6001; Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor with Ki values of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM and 0.36 nM for MMPs -1, -2, -3, -7, -8, -9, -12, -14 and -26, respectively. Ilomastat (GM6001; Galardin) reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. | ||
| M1487 | D-Galactosamine hydrochloride | Animal Modeling |
| D(+)-Galactosamine hydrochloride | ||
| D-Galactosamine hydrochloride is usually used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research. | ||
| M4186 | Polygalacic-acid | Others |
| Polygalacic-acid | ||
| M4191 | Polygalaxanthone-III | Cytochrome P450 (e.g. CYP17) |
| Polygalaxanthone III was extracted from Polygala Tenuifolia Wild and had inhibitory effects on CYP450. Polygalaxanthone III inhibited the 6-hydroxylation of clozoxazone catalyzed by CYP2E1 with IC50 of 50.56μM. | ||
| M4539 | Polygalasaponin-F | TLR |
| Polygalasaponin F is an oleanane type triterpenoid saponin extracted from Polygala Japonica, which can reduce the release of inflammatory cytokine tumor necrosis factor α (TNFa). Polygalasaponin F reduces the secretion of neuroinflammatory cytokines by regulating the TLR4-PI3K/ Akt-NF-KB signaling pathway. | ||
| M4615 | 2-O-beta-L-galactopyranosylorientin | Others |
| 2" -o-beta-l-galactopyrano sylorientin extracted from the flower of Trollius Ledebouri. 2" -o-beta-l-galactopyrano sylorientin is involved in transporter-mediated efflux and is a substrate for multidrug-resistant protein 2 (MRP2). It has anti-inflammatory effects. | ||
| M4699 | Galangin | Cytochrome P450 (e.g. CYP17) |
| 3,5,7-Trihydroxyflavone; Norizalpinin | ||
| Galangin (Norizalpinin) is a regulator of arylhydrocarbon receptors and also inhibits the activity of CYP1A1. | ||
| M5672 | Galanthamine HBr | AChR/AChE |
| Galantamine hydrobromide | ||
| Galanthamine HBr is an alkaloid derived from lithophyllum and also a reversible AChE inhibitor with an IC50 of 0.35 μM, which is 50-fold more selective than that used for butyrylcholinesterase. It can be used in studies related to Alzheimer's disease (AD). | ||
| M5725 | Lactulose | Metabolite/Endogenous Metabolite |
| 4-O-β-D-Galactopyranosyl-D-fructose | ||
| Lactulose, a disaccharide composed of galactose and fructose, is a stimulator of health-promoting bacterium growth in the gastrointestinal tract. | ||
| M6834 | IPTG | Others |
| Isopropyl β-D-thiogalactoside | ||
| IPTG is a used in cloning procedures with X-GAL. | ||
| M9322 | 2-Nitrophenyl β-D-galactopyranoside | Others |
| ONPG | ||
| ONPG (2-Nitrophenyl β-D-galactopyranoside) is a colorimetric and spectrophotometric substrate for detection of β-galactosidase activity. | ||
| M9926 | Polygalasaponin XXXI | Adjuvants |
| Onjisaponin F | ||
| Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine. | ||
| M9976 | D-Galactose | Animal Modeling |
| D-(+)-Galactose | ||
| D-Galactose is a natural aldohexose and C-4 epimer of glucose, it accelerates the aging of invertebrates and mammals and is used as a model of aging. | ||
| M10045 | Lactitol | Antibiotic |
| 4-β-D-galactopyranosyl-D-glucito1 | ||
| Lactitol is a versatile, reduced calorie sweetener derived from natural milk sugar, used in a wide variety of sweetening applications. | ||
| M10051 | UDP-Galactose | Metabolite/Endogenous Metabolite |
| UDP-Gal | ||
| UDP-Galactose is a nucleotide sugar. UDP-Galactose acts as a natural agonist for Gi protein-conjugated P2Y14 receptors in the immune system with IC50 of 0.67 μM for hP2Y14. | ||
| M10067 | Ac4GalNAz | PROTAC |
| N-azidoacetylgalactosamine-tetraacylated | ||
| Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | ||
| M10093 | α-Galactosyl Ceramide | Immunology/Inflammation |
| KRN7000 | ||
| α-Galactosyl Ceramide (KRN 7000, alpha-GalCer) is a potent NKT cell stimulator and selective CD1d ligand. α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. | ||
| M10264 | 4-Methylumbelliferyl α-D-galactopyranoside | Fluorescent Dye |
| 4MU-α-Gal | ||
| 4-Methylumbelliferyl α-D-galactopyranoside is a blue pro-fluorogenic substrate. 4-Methylumbelliferyl-α-D-galactopyranoside forms two products, galactose and fluorescent 4MU, upon cleavage by GLA. | ||
| M10428 | N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) | Metabolite/Endogenous Metabolite |
| D-GalNAc | ||
| N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) is an endogenous metabolite, it is the important constituent of brain heteropolysaccharides (glycoproteins). | ||
| M11135 | DELPHINIDIN-3-O-GALACTOSIDE | Others |
| Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity. D3G is capable of masking the EGCG-induced cytotoxicity and ER stress, presumably through up-regulation of antioxidant enzymes and heat shock proteins. | ||
| M13517 | Polygalacin D | Apoptosis |
| Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties. | ||
| M13636 | VAL-083 | Others |
| Dianhydrodulcitol; Dianhydrogalactitol | ||
| VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity. | ||
| M13784 | Fluorescein di (β-D-galactopyranoside) | Fluorescent Dye |
| FDG | ||
| Fluorescein di (β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λex=485 nm, λem=535 nm). | ||
| M14548 | Galanthamine | AChR/AChE |
| Galantamine | ||
| Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM. | ||
| M14975 | Kaempferol 3-O-β-D-galactopyranoside | Others |
| Trifolin | ||
| Kaempferol 3-O-β-D-galactopyranoside (Trifolin) is a derivative of flavonoid, which is isolated from the aerial part of Consolida oliveriana. | ||
| M14998 | Isorhamnetin 3-O-galactoside | Others |
| Cacticin | ||
| Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. | ||
| M16237 | Galanganone A | Chalcones |
| Galanganone A | ||
| M16477 | Galanolactone | Diterpenoids |
| Galanolactone | ||
| M16577 | 6-Methoxykaempferol 3-O-galactoside | Flavonoids |
| 6-Methoxykaempferol 3-O-galactoside | ||
| M16614 | Quercetin 4'-O-galactoside | Flavonoids |
| Quercetin 4'-O-galactoside | ||
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