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Polygalasaponin XXXI

Cat. No. M9926
Polygalasaponin XXXI Structure
Synonym:

Onjisaponin F

Size Price Availability
5mg USD 300  USD300 4-7 Days
25mg USD 900  USD900 4-7 Days
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Quality Control & Documentation
Biological Activity

Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine. Polygalasaponin XXXI (Onjisaponin F) also enhances anti-HA IgA and IgG Ab titers in the nasal wash. Polygalasaponin XXXI can induce protective immunity against intranasal infection by influenza virus. Polygalasaponin XXXI (Onjisaponin F) also induces ChAT mRNA level in rat basal forebrain cells.

Chemical Information
Molecular Weight 1589.67
Formula C75H112O36
CAS Number 79103-90-5
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] T Yabe, et al. Phytomedicine. Induction of NGF synthesis in astrocytes by onjisaponins of Polygala tenuifolia, constituents of kampo (Japanese herbal) medicine, Ninjin-yoei-to

[2] T Nagai, et al. Vaccine. Onjisaponins, from the root of Polygala tenuifolia Willdenow, as effective adjuvants for nasal influenza and diphtheria-pertussis-tetanus vaccines

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