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Ac4GalNAz

Cat. No. M10067
Ac4GalNAz Structure
Synonym:

N-azidoacetylgalactosamine-tetraacylated

Size Price Availability Quantity
5mg USD 75  USD75 In stock
10mg USD 115  USD115 In stock
25mg USD 220  USD220 In stock
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Quality Control & Documentation
Biological Activity

Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Chemical Information
Molecular Weight 430.37
Formula C16H22N4O10
CAS Number 653600-56-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sainan An, et al. EBioMedicine. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drμgs

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  Catalog
Abmole Inhibitor Catalog




Keywords: Ac4GalNAz, N-azidoacetylgalactosamine-tetraacylated supplier, PROTAC, inhibitors, activators


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