About 30 results found for searched term "EP6" (0.031 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1859 | RepSox (ALK5 Inhibitor II) | ALK |
| RepSox; E-616452; SJN 2511; 616452 | ||
| RepSox (ALK5 Inhibitor II) is a potent and ATP-competitive inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). | ||
| M1908 | VER-82576 | HSP |
| NVP-BEP800; VER82576 | ||
| VER-82576 (NVP-BEP800) is a potent, orally available and selective inhibitor of Hsp90β with an IC50 of 58 nM. VER-82576 also slightly blocks Grp94 and Trap-1, with IC50s of 4.1 and 5.5 μM, respectively. | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2045 | CEP-32496 | Raf |
| RXDX-105; Agerafenib | ||
| CEP-32496 is a potent orally active BRAF inhibitor with IC50 of 14 nM. | ||
| M2179 | EPZ-5676 | Histone Methyltransferase |
| Pinometostat | ||
| EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase. | ||
| M2676 | EPZ005687 | EZH2 |
| EPZ005687 is a potent, selective EZH2 inhibitor,Ki The value is 24 nM, which is 50 times more selective than EZH1 and 500 times more selective than 15 other methyltransferases. | ||
| M3447 | PF-2545920 | PDE |
| Mardepodect; CAS# 898562-94-2 | ||
| PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE. | ||
| M3942 | Cephalotaxine | Anti-infection |
| (-)-Cephalotaxine; ZINC19795976 | ||
| Cephalotaxine is a benzazepine alkaloid isolated from Cephalotaxus harringtonia. | ||
| M4954 | EPZ015666 | PRMTs |
| GSK3235025 | ||
| EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs. | ||
| M5160 | Reparixin | CXCR |
| Repertaxin; DF 1681Y | ||
| Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors with IC50 of 1 and 100 nM, respectively. | ||
| M5373 | 6-Aminocaproic acid | Others |
| EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid | ||
| 6-Aminocaproic acid (EACA) is a derivative and analogue of the amino acid lysine, it is also a potent and orally active inhibitor of plasmin and plasminogen. | ||
| M6278 | Epothilone D | Microtubule |
| 12,13-Desoxyepothilone B; Desoxyepothilone B; KOS 862 | ||
| Epothilone D is a potent microtubule stabilizer. | ||
| M6336 | 3-Deazaneplanocin A hydrochloride | Histone Methyltransferase |
| DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride | ||
| 3-Deazaneplanocin A hydrochloride（DZNep HCl） is a eZH2 histone methyltransferase inhibitor. | ||
| M6504 | Olcegepant (BIBN-4096) | CGRP Receptor |
| BIBN-4096; BIBN 4096BS | ||
| Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide (CGRP) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP. | ||
| M7904 | Methiothepin mesylate salt | Others |
| Metitepine mesylate; Ro 8-6837 mesylate | ||
| Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors. | ||
| M8649 | GSK591 | PRMTs |
| GSK-591; GSK3203591; EPZ015866 | ||
| GSK591 (EPZ015866) is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 4 nM. | ||
| M8825 | Adenosine A1 receptor activator T62 | Adenosine Receptor |
| Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. | ||
| M9001 | ML-265 (TEPP-46) | Pyruvate Kinase |
| TEPP-46; ML265 | ||
| Ml-265 (TEPP-46) is an effective activator of pyruvate kinase M2 (PKM2). | ||
| M9420 | GSK3326595 | PRMTs |
| EPZ015938; GSK-3326595 | ||
| GSK3326595 is a potent, reversible and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with broad antiproliferative activity for studies related to lymphoma and leukemia. | ||
| M9567 | Leptin (116-130) mouse | Others |
| LEP(116-130) mouse | ||
| Leptin (116-130) mouse is a synthetic leptin peptide fragment. | ||
| M9771 | TRAP-6 | Peptides |
| Thrombin Receptor Activator Peptide 6; PAR-1 agonist peptide | ||
| TRAP-6 (Thrombin Receptor Activator Peptide 6) is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. | ||
| M10233 | ((Cys31,Nva34)-Neuropeptide Y (27-36))2 | Neuropeptide Receptor |
| BWX 46 | ||
| ((Cys31,Nva34)-Neuropeptide Y (27-36))2, also called BWX 46, is a neuropeptide Y (NPY) Y5 receptor selective agonist. | ||
| M10427 | OVA Peptide (257-264) TFA | Peptides |
| OVA Peptide (257-264) TFA is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide from ovalbumin presented by the class I MHC molecule, H-2Kb. | ||
| M10489 | NEO2734 (EP31670) | Epigenetic Reader Domain |
| EP31670; NEO-2734 | ||
| NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM. | ||
| M10532 | Tazemetostat hydrobromide | Histone Methyltransferase |
| EPZ-6438 hydrobromide; Tazemetostat HBr | ||
| Tazemetostat (EPZ-6438) hydrobromide is a first-in-class potent, selective and orally available EZH2 inhibitor. | ||
| M10961 | Ralaniten triacetate | Androgen Receptor |
| EPI-506 | ||
| Ralaniten triacetate (EPI-506), a prodrug for Ralaniten, is a pioneering, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate is active against full-length and resistance-related AR species, including AR-v7. | ||
| M11319 | GLP-1(7-36), amide TFA | GLP Receptor |
| Glucagon-like peptide-1 (GLP-1)(7-36), amide TFA; Human GLP-1 (7-36), amide TFA | ||
| TFA is a major intestinal hormone that stimulates insulin secretion by pancreatic beta cells in response to glucose. | ||
| M25417 | Masofaniten | Androgen Receptor |
| Androgen receptor-IN-2; EPI-7386 | ||
| Masofaniten (Androgen receptor-IN-2) is a potent and orally active androgen receptor inhibitor. Masofaniten inhibits androgen binding to androgen receptor with IC50 of 535 nM in the androgen-induced PSA-Luciferase assay. | ||
| M13968 | GLP-1(7-36), amide acetate | GLP Receptor |
| Glucagon-like peptide-1 (GLP-1)(7-36), amide acetate; Human GLP-1 (7-36), amide acetate | ||
| GLP-1(7-36), amide acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells. | ||
| M14026 | Peptide YY (PYY) (3-36), porcine TFA | Others |
| Peptide YY (PYY) (3-36), porcine TFA is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite. | ||
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