GLP-1(7-36), amide acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.
| Molecular Weight | 3357.73 |
| CAS Number | 1119517-19-9 |
| Solubility (25°C) | Water 90 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related GLP Receptor Products |
|---|
| GLP-1 receptor agonist 12
GLP-1 receptor agonist 12 is an agonist of GLP Receptor. |
| GLP-1 receptor agonist 11
GLP-1 receptor agonist 11 is an agonist of GLP Receptor. |
| GLP-1 receptor agonist 10
GLP-1 receptor agonist 10 is an agonist of GLP Receptor. |
| GLP-1 receptor agonist 13
GLP-1 receptor agonist 13 is a glucagon GLP-1 receptor agonist with EC50 of 76 nM. |
| LSN3160440
LSN3160440 is an allosteric modulator of GLP-1R, which acts as a protein–protein interaction (PPI) stabilizer or molecular glue to assist in the adhesion of inactive GLP-1 (9-36) NH2 on GLP-1R. |
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