Free shipping on all orders over $ 500

GSK3326595

Cat. No. M9420
GSK3326595 Structure
Synonym:

EPZ015938; GSK-3326595

Size Price Availability Quantity
5mg USD 40  USD40 In stock
10mg USD 67  USD67 In stock
50mg USD 227  USD227 In stock
100mg USD 397  USD397 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM.

Chemical Information
Molecular Weight 452.55
Formula C24H32N6O3
CAS Number 1616392-22-3
Solubility (25°C) DMSO ≥ 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuhong Luo, et al. Hepatology. MYC-Protein Arginine Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma

[2] Hyungsoo Kim, et al. Sci Transl Med. PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity

[3] Shatha AbuHammad, et al. Proc Natl Acad Sci U S A. Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

[4] Hong Lin, et al. Bioorg Med Chem Lett. Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors

Related PRMTs Products
TNG908

TNG908 is a PRMT5 inhibitor that crosses the blood-brain barrier and can be used in studies related to advanced solid tumors.

PRMT5-IN-20 

PRMT5-IN-20 is a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with anti-tumor activity.

PRMT5-IN-2 

PRMT5-IN-2 is a rotein arginine methyltransferase 5 (PRMT5) inhibitor.

SGC2085 hydrochloride 

SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC50 of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins.

PF-06939999

PF-06939999 (PRMT5-IN-3) is a PRMT5 inhibitor that is synthetically lethal to tumor cells in combination with DNA damaging agents.

  Catalog
Abmole Inhibitor Catalog




Keywords: GSK3326595, EPZ015938; GSK-3326595 supplier, PRMTs, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.