| Cat.No. | Name | Information |
|---|---|---|
| M31291 | TNG908 | TNG908 is a PRMT5 inhibitor that crosses the blood-brain barrier and can be used in studies related to advanced solid tumors. |
| M13849 | MS023 dihydrochloride | MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively. |
| M13371 | Onametostat (JNJ-64619178) | Onametostat (JNJ-64619178) is a highly selective, orally active, pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (PRMT5-MEP-50, IC50=0.14 nM).Onametostat does not covalently bind to PRMT5, but has a long interaction time. It has good pharmacokinetic properties as well as safety profile. |
| M11055 | TP-064 | TP-064 is a potent and selective PRMT4 small molecule inhibitor with ic50 < 10 nM, which is more than 100 times more selective for PRMT4 than other PRMT. |
| M10954 | MRTX9768 hydrochloride | MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. |
| M10953 | MRTX-1719 | MRTX-1719 is a potent, first-of-its-kind, selective PRMT5/MTA complex inhibitor against PRMT5/MTA MTAPDEL SDMA CELL LINES IC50 The value is <10 nM. |
| M10637 | GSK3368715 2HCl | GSK3368715 2HCl is a novel potent, orally active, reversible type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50 values of 3.1 nM, 48 nM, 1148 nM, 5.7 nM and 1.7 nM for PRMT1, PRMT3, PRMT4, PRMT6, PRMT8, respectively. |
| M10495 | AMI-1 disodium salt | AMI-1 is a potent and selective, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50 values of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 is also a potent scavenger of NADPH-oxidase-derived superoxide. |
| M10073 | HLCL-61 hydrochloride | HLCL-61 hydrochloride is a potent and selective, first-in-class protein arginine methyltransferase 5 (PRMT5) inhibitor. |
| M9789 | MS049 | MS049 is a potent and selective inhibitor of PRMT4,6 with IC50 values of 34 nM and 43 nM, respectively. |
| M9420 | GSK3326595 | GSK3326595 is a potent, reversible and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with broad antiproliferative activity for studies related to lymphoma and leukemia. |
| M9003 | MS023 | MS023 is a potent and selective, cell-active inhibitor of type I PRMTs with IC50s of 4-119 nM. |
| M8649 | GSK591 | GSK591 (EPZ015866) is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 4 nM. |
| M7365 | TC-E 5003 | Tc-e 5003 is a selective inhibitor of PRMT1 with an IC50 of 1.5 µM against hPRMT1. Tc-e 5003 has anti-inflammatory properties in TLR4 signal transduction. |
| M6312 | LLY-283 | LLY-283 is the potent and selective SAM-competitive chemical probe for PRMT5. It inhibits PRMT5 enzyme activity with IC50 of 20 nM for methylation of an H4R3 derived peptide substrate, and shows greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. |
| M6177 | SGC2085 | SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs. |
| M6142 | XY1 | XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), but XY1 is completely inactive. |
| M5229 | EPZ020411 | EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ＞10 fold selectivity for PRMT6 over PRMT1 and PRMT8. |
| M5163 | SGC707 | SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively. |
| M4954 | EPZ015666 | EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs. |
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