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HLCL-61 hydrochloride

Cat. No. M10073

All AbMole products are for research use only, cannot be used for human consumption.

HLCL-61 hydrochloride Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 50  USD50 In stock
10mg USD 75  USD75 In stock
25mg USD 130  USD130 In stock
50mg USD 195  USD195 In stock
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Quality Control & Documentation
Biological Activity

HLCL-61 hydrochloride is a potent and selective, first-in-class protein arginine methyltransferase 5 (PRMT5) inhibitor. HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 hydrochloride reduces cells growth at dose-dependent manner with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.

Chemical Information
Molecular Weight 380.91
Formula C23H24N2O.HCl
CAS Number 1158279-20-9
Solubility (25°C) DMSO 49 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month

[1] S S Tarighat, et al. Leukemia. The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation

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Abmole Inhibitor Catalog

Keywords: HLCL-61 hydrochloride supplier, PRMTs, inhibitors, activators

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