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PRMTs Protein arginine methyltransferases

Cat.No.  Name Information
M8649 GSK591 GSK591 (EPZ015866) is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 4 nM.
M5163 SGC707 SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.
M4954 EPZ015666 EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.
M3783 C7280948 C7280948 is an inhibitor of histone arginine methyltransferase PRMT1 with IC50 values of 12.75 uM.
M50219 AMG-193 AMG-193 is an orally active inhibitor of the PRMT5/MTA complex for studies related to solid tumors. AMG-193 (PRMT5-IN-27) inhibits HCT116 cell proliferation with an IC 50 of 0.13 μM.
M50215 AZD3470 AZD3470 is a novel PRMT5 inhibitor targeting the MTA and PRMT5 complex for studies related to hematologic tumors.
M30800 PRMT5-IN-20  PRMT5-IN-20 is a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with anti-tumor activity.
M29080 PRMT5-IN-2  PRMT5-IN-2 is a rotein arginine methyltransferase 5 (PRMT5) inhibitor.
M28928 SGC2085 hydrochloride  SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC50 of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins.
M21075 PF-06939999 PF-06939999 (PRMT5-IN-3) is a PRMT5 inhibitor that is synthetically lethal to tumor cells in combination with DNA damaging agents.
M13847 EZM 2302 EZM 2302 is an inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1) with an IC50 of 6 nM.
M13845 CARM1-IN-1 hydrochloride CARM1-IN-1 hydrochloride is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM).
M13844 CARM1-IN-1 CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM).
M10952 BRD0639 BRD0639 is a first-in-class inhibitor of PRMT5-substrate aptamer interactions.BRD0639 is a PRMT5-binding motif (PBM) competitor that supports studies of PBM-dependent PRMT5 activity.
M10951 CMP-5 CMP-5 is a potent and selective PRMT5 inhibitor that is inactive against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity during histone preparation. CMP-5 blocks EBV-driven B lymphocyte transformation but has no effect on normal B cells.
M8561 DS-437 DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.
M8379 CID 5380390 CID 5380390 is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8.
M7456 UNC 2327 UNC 2327 is a allosteric inhibitor of PRMT3.
M6737 Furamidine dihydrochloride Furamidine dihydrochloride is a selective PRMT1 inhibitor.




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