| Cat.No. | Name | Information |
|---|---|---|
| M3783 | C7280948 | C7280948 is an inhibitor of histone arginine methyltransferase PRMT1 with IC50 values of 12.75 uM. |
| M50219 | AMG 193 | AMG 193 is an orally active inhibitor of the PRMT5/MTA complex for studies related to solid tumors. |
| M50215 | AZD3470 | AZD3470 is a novel PRMT5 inhibitor targeting the MTA and PRMT5 complex for studies related to hematologic tumors. |
| M41687 | TNG-462 | TNG-462 is an orally active PRMT5 inhibitor for investigation of MTAP-deficient and/or MTA-accumulating cancers. |
| M30800 | PRMT5-IN-20 | PRMT5-IN-20 is a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with anti-tumor activity. |
| M29080 | PRMT5-IN-2 | PRMT5-IN-2 is a rotein arginine methyltransferase 5 (PRMT5) inhibitor. |
| M28928 | SGC2085 hydrochloride | SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC50 of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins. |
| M21075 | PF-06939999 | PF-06939999 (PRMT5-IN-3) is a PRMT5 inhibitor that is synthetically lethal to tumor cells in combination with DNA damaging agents. |
| M13847 | EZM 2302 | EZM 2302 is an inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1) with an IC50 of 6 nM. |
| M13845 | CARM1-IN-1 hydrochloride | CARM1-IN-1 hydrochloride is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). |
| M13844 | CARM1-IN-1 | CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). |
| M11033 | EPZ020411 hydrochloride | EPZ020411 hydrochloride is a potent and selective PRMT6 inhibitor, IC50 10 nM, which is more than 10 times more selective than acting on PRMT1 and PRMT8. |
| M10952 | BRD0639 | BRD0639 is a first-in-class inhibitor of PRMT5-substrate aptamer interactions.BRD0639 is a PRMT5-binding motif (PBM) competitor that supports studies of PBM-dependent PRMT5 activity. |
| M10951 | CMP-5 | CMP-5 is a potent and selective PRMT5 inhibitor that is inactive against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity during histone preparation. CMP-5 blocks EBV-driven B lymphocyte transformation but has no effect on normal B cells. |
| M8561 | DS-437 | DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5. |
| M8379 | CID 5380390 | CID 5380390 is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8. |
| M7456 | UNC 2327 | UNC 2327 is a allosteric inhibitor of PRMT3. |
| M6737 | Furamidine dihydrochloride | Furamidine dihydrochloride is a selective PRMT1 inhibitor. |
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