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CMP-5

Cat. No. M10951
CMP-5 Structure
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Biological Activity

CMP-5 is a potent and selective PRMT5 inhibitor that is inactive against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity during histone preparation. CMP-5 blocks EBV-driven B lymphocyte transformation but has no effect on normal B cells.

Chemical Information
Molecular Weight 315.41
Formula C21H21N3
CAS Number 880813-42-3
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yusuf Simsek, et al. J Mol Graph Model. In silico identification of SARS-CoV-2 cell entry inhibitors from selected natural antivirals

[2] John B McArthur, et al. Org Biomol Chem. L. pneumophila CMP-5,7-di-N-acetyllegionaminic acid synthetase (LpCLS)-involved chemoenzymatic synthesis of sialosides and analogues

[3] Stephan Krapp, et al. J Mol Biol. The crystal structure of murine CMP-5-N-acetylneuraminic acid synthetase

[4] C H Lin, et al. Biochemistry. Why is CMP-ketodeoxyoctonate highly unstable?

[5] A B Cubitt, et al. Biochem J. 5'-CMP stimulates phospholipase A-mediated hydrolysis of phosphatidylinositol in permeabilized pituitary GH3 cells

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