About 6 results found for searched term "CMP-5" (0.144 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10951 | CMP-5 | PRMTs |
| CMP-5 is a potent and selective PRMT5 inhibitor that is inactive against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity during histone preparation. CMP-5 blocks EBV-driven B lymphocyte transformation but has no effect on normal B cells. | ||
| M21616 | Cytidine-5'-monophospho-N-acetylneuraminic acid | Metabolite/Endogenous Metabolite |
| CMP-Neu5Ac; CMP-Sialic Acid, Monosodium Salt | ||
| Cytidine-5'-monophospho-N-acetylneuraminic acid is a nucleotide. | ||
| M27667 | CMP-5 hydrochloride | Histone Methyltransferase |
| CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected. | ||
| M40607 | CCR7 Ligand 1 | CCR |
| CCR7-Cmp2105 | ||
| CCR7 Ligand 1 (CCR7-Cmp2105) is a human CC chemokine receptor 7 (CCR7) variant ligand and a potent intracellular CCR7 receptor variant antagonist with a Kd value of 3 nM. In addition, CCR7 Ligand 1 also inhibited CCL19 activation with an IC50 value of 7.3 μM. | ||
| M20981 | BI-671800 | Prostaglandin Receptor |
| AP-761, Cmpd A | ||
| BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS. | ||
| M30695 | CMP8 | Estrogen Receptor |
| CMP8, a selective ligand for estrogen receptor, binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 exhibits IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively. | ||
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