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Cytidine-5'-monophospho-N-acetylneuraminic acid

Cat. No. M21616
Cytidine-5'-monophospho-N-acetylneuraminic acid Structure
Synonym:

CMP-Neu5Ac; CMP-Sialic Acid, Monosodium Salt

Size Price Availability Quantity
1mg USD 145  USD145 In stock
5mg USD 190  USD190 In stock
25mg USD 400  USD400 In stock
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Biological Activity

Cytidine-5'-monophospho-N-acetylneuraminic acid is a nucleotide.

Chemical Information
Molecular Weight 614.45
Formula C20H31N4O16P
CAS Number 3063-71-6
Solubility (25°C) Soluble in water
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yumiko Uno, et al. Canine Genet Epidemiol. Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase ( CMAH) associated with the erythrocyte antigens in dogs

[2] Meng Fang, et al. Biomed Chromatogr. Quantitation of cytidine-5'-monophospho-N-acetylneuraminic acid in human leukocytes using LC-MS/MS: method development and validation

[3] Kwon-Ho Song, et al. Sci Rep. Intestine specific regulation of pig cytidine-5'-monophospho-N-acetylneuraminic acid hydroxylase gene for N-glycolylneuraminic acid biosynthesis

[4] E V Chandrasekaran, et al. Biochemistry. Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products

[5] Tomoki Hamamoto, et al. Biosci Biotechnol Biochem. Enzymatic synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid

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Keywords: Cytidine-5'-monophospho-N-acetylneuraminic acid, CMP-Neu5Ac; CMP-Sialic Acid, Monosodium Salt supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

 
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