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MS023 dihydrochloride

Cat. No. M13849
MS023 dihydrochloride Structure
Size Price Availability Quantity
5mg USD 108  USD108 In stock
10mg USD 175  USD175 In stock
25mg USD 328  USD328 In stock
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Quality Control & Documentation
Biological Activity

MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.

Chemical Information
Molecular Weight 360.32
CAS Number 1992047-64-9
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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  Catalog
Abmole Inhibitor Catalog




Keywords: MS023 dihydrochloride supplier, PRMTs, inhibitors, activators


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