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AMI-1 disodium salt

Cat. No. M10495
AMI-1 disodium salt Structure


Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 80  USD80 In stock
25mg USD 160  USD160 In stock
50mg USD 230  USD230 In stock
100mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

AMI-1 is a potent and selective, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50 values of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 is also a potent scavenger of NADPH-oxidase-derived superoxide. AMI-1 specifically inhibits arginine, but not lysine, methyltransferase activity in vitro and does not compete for the AdoMet binding site. AMI-1 inhibits methylation of GFP-Npl3 and cellular proteins.

In vivo, AMI-1 (5 μg/rat) in chronic AIPI rats ameliorates COX2 expression and asthmatic indexes, and decreases the airway and alveoli lesions, mucus secretion, and collagen deposition in lungs.

Chemical Information
Molecular Weight 548.45
Formula C21H14N2Na2O9S2
CAS Number 20324-87-2
Solubility (25°C) DMSO 45 mg/mL
Water 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Baolai Zhang, et al. Oncol Lett. Arginine methyltransferase inhibitor-1 inhibits sarcoma viability in vitro and in vivo

[2] Baolai Zhang, et al. Oncotarget. Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3

[3] Qingzhu Sun, et al. J Immunol. PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation

[4] Donghang Cheng, et al. J Biol Chem. Small molecule regulators of protein arginine methyltransferases

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Keywords: AMI-1 disodium salt, AMI1 supplier, PRMTs, inhibitors, activators

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