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Masofaniten (Androgen receptor-IN-2) is a potent and orally active androgen receptor inhibitor. Masofaniten inhibits androgen binding to androgen receptor with IC50 of 535 nM in the androgen-induced PSA-Luciferase assay.
Masofaniten inhibits cell proliferation in LNCaP and LNCaP95 cells with IC50 values of 0.44 μM and 3.78 μM respectively.
Masofaniten (60 mg/kg, p.o.) induces partial regressions of tumor growth in NCG mice bearing LNCaP tumors.
| Molecular Weight | 535.44 |
| Formula | C24H24Cl2N4O4S |
| CAS Number | 2416716-62-4 |
| Solubility (25°C) | DMSO 50 mg/mL (ultrasonic and warming) |
| Storage | -20°C, sealed |
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