About 21 results found for searched term "DCA" (0.052 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2507 | Chenodeoxycholic acid | Farnesoid X Receptor |
| CDCA; Chenodiol | ||
| Chenodeoxycholic acid is an epimer of ursodeoxycholic acid, which inhibits the production of cholesterol in the liver and absorption in the intestines. | ||
| M3775 | Obeticholic Acid (INT-747) | Farnesoid X Receptor |
| 6-ECDCA; UNII-0462Z4S4OZ; OCA; 6-Ethylchenodeoxycholic acid | ||
| Obeticholic Acid (INT-747) is a potent, orally active, selective farnesoid X receptor (FXR) agonist with an EC50 of 99 nM.May be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M5158 | Tauroursodeoxycholic acid (Ursodoxicoltaurine) | ERK |
| TUDCA; Ursodoxicoltaurine; Ursodeoxycholyltaurine; Tauroursodeoxycholate; UR 906; Taurursodiol | ||
| Tauroursodeoxycholic acid (Ursodoxicoltaurine) is an endoplasmic reticulum stress inhibitor. It can significantly reduce the expression of apoptotic molecules such as caspase-3 and caspase-12. Tauroursodeoxycholate also suppresses ERK. It is a taurine conjugate of usodeoxycholic acid. | ||
| M5340 | Tauroursodeoxycholate Sodium | ERK |
| TUDCA; Sodium tauroursodeoxycholate; Tauroursodeoxycholic acid sodium salt | ||
| Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis. | ||
| M6047 | Ursodiol | Animal Modeling |
| UDCA；Ursodeoxycholic acid; UDCS；Ursodeoxycholate; Ursodiol | ||
| Ursodiol reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones with an IC50 of 0.22 μM. Ursodeoxycholic acid (UDCA), which reduces FXR and closes the ACE2 channel. It can be used to construct animal models of cholelithiasis. | ||
| M6656 | DCA | Others |
| Sodium dichloroacetate | ||
| DCA (Sodium dichloroacetate) is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor. | ||
| M8378 | DCAP | Others |
| DCAP is a potent broad-spectrum antibiotic that specifically targets the membranes of both Gram-positive and Gram-negative bacteria. | ||
| M8632 | DCAI | Others |
| DCAI, an Inactive Ras, is bound to a GDP and activated by SOS (son of sevenless, among others), which converts it to the active GTP form. | ||
| M11178 | Taurochenodeoxycholic acid | Apoptosis |
| Taurochenodeoxycholate, TCDCA, 12-Deoxycholyltaurine, Chenodeoxycholyltaurine, Chenyltaurine | ||
| Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animal bile acids. Taurochenodeoxycholic acid induces apoptosis (apoptosis) and has a pronounced anti-inflammatory and immunomodulatory effect. | ||
| M11414 | Hyodeoxycholic acid | Metabolite/Endogenous Metabolite |
| HDCA; NSC 60672 | ||
| Hyodeoxycholic acid is a secondary bile acid formed by intestinal flora in the small intestine and is an agonist of TGR5 (GPCR19). In CHO cells, the EC50 value is 31.6 µM. | ||
| M20548 | 2,4-Pyridinedicarboxylic acid | Others |
| Lutidinic Acid; 2,4-Dicarboxypyridine; 2,4-PDCA | ||
| 2,4-Pyridinedicarboxylic acid is a compound that structurally mimics 2-oxoglutarate (2-OG) and chelates zinc, thus affecting a range of enzymes. It blocks the activity of 2-OG oxygenases. | ||
| M21462 | 24-Norursodeoxycholic acid | Others |
| nor-UDCA | ||
| 24 norursodeoxycholic acid (nor UDCA) is a C23 homologue of UDCA with shortened side chain, which has effective anti cholestasis, anti-inflammatory and anti fibrosis properties. | ||
| M27695 | Hyodeoxycholic acid sodium | Others |
| HDCA sodium | ||
| Hyodeoxycholic acid sodium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||
| M28700 | Honokiol DCA | Androgen Receptor |
| Honokiol dichloroacetate; HDCA | ||
| Honokiol DCA (Honokiol dichloroacetate) is a dichloroacetate analog of Honokiol. Honokiol DCA can inhibit the growth of human prostate cancer cells in vitro and suppress the androgen receptor (AR) protein level. | ||
| M42834 | DCA-RMR1 | Others |
| DCA-RMR1 is a cross-linker. | ||
| M43153 | CYCA-117-70 | Ligand for E3 Ligase |
| CYCA-117-70 is a DCAF1 ligand (KD: 70 μM). CYCA-117-70 is an ideal chemical handles for PROTACs recruiting DCAF1. | ||
| M43422 | DCAF1 binder 1 | Ligand for E3 Ligase |
| DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. | ||
| M50184 | Berberine ursodeoxycholate | Others |
| HTD1801; BUDCA | ||
| Berberine ursodeoxycholate is an ionic salt of Berberine and Ursodeoxycholic acid and an orally effective lipid modulator that significantly reduces hepatic fat content.Berberine ursodeoxycholate has been used in studies related to hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes. | ||
| M58123 | OICR-8268 | Ligand for E3 Ligase |
| OICR8268 | ||
| OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. OICR-8268 can be used in the development of DCAF1-based PROTACs. | ||
| M55699 | Taurohyodeoxycholic acid sodium | IL Receptor/Related |
| THDCA sodium | ||
| Taurohyodeoxycholic acid (THDCA) sodium prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurohyodeoxycholic acid sodium can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model. | ||
| M57949 | 23(S)-Me-UDCA | Others |
| 23(S)-Me-UDCA | ||
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