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Obeticholic Acid (INT-747) is a potent, orally active, selective farnesoid X receptor (FXR) agonist with an EC50 of 99 nM.May be used in studies related to non-alcoholic steatohepatitis (NASH).
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Source | PLoS One (2013). Figure 3. INT-747 |
| Method | H&E staining | |
| Cell Lines | Dahl salt-sensitive (SS/JrHsd) male | |
| Concentrations | 10 mg/kg/day | |
| Incubation Time | 6 weeks | |
| Results | Furthermore, INT-747 did not improve renal pathology in the HS-fed animals. In all HS animals, severe thrombotic microangiopathy (TMA) was observed as well as fibrinoid necrosis of afferent arterioles with an onion-skin pattern of periarterial fibrosis and extravasation of erythrocytes |
| Molecular Weight | 420.63 |
| Formula | C26H44O4 |
| CAS Number | 459789-99-2 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Fiorucci S, et al. Expert Opin Ther Targets. Targeting FXR in cholestasis: hype or hope.
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