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Obeticholic Acid (INT-747)

Cat. No. M3775
Obeticholic Acid (INT-747) Structure

6-ECDCA; UNII-0462Z4S4OZ; OCA; 6-Ethylchenodeoxycholic acid

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 35  USD35 In stock
10mg USD 50  USD50 In stock
50mg USD 90  USD90 In stock
100mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

Obeticholic Acid (INT-747) is a potent, orally active, selective farnesoid X receptor (FXR) agonist with an EC50 of 99 nM.May be used in studies related to non-alcoholic steatohepatitis (NASH).

Customer Product Validations & Biological Datas
Source PLoS One (2013). Figure 3. INT-747
Method H&E staining
Cell Lines Dahl salt-sensitive (SS/JrHsd) male
Concentrations 10 mg/kg/day
Incubation Time 6 weeks
Results Furthermore, INT-747 did not improve renal pathology in the HS-fed animals. In all HS animals, severe thrombotic microangiopathy (TMA) was observed as well as fibrinoid necrosis of afferent arterioles with an onion-skin pattern of periarterial fibrosis and extravasation of erythrocytes
Chemical Information
Molecular Weight 420.63
Formula C26H44O4
CAS Number 459789-99-2
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Neuschwander-Tetri BA, et al. Lancet. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial.

[2] Fiorucci S, et al. Expert Opin Ther Targets. Targeting FXR in cholestasis: hype or hope.

[3] Ghebremariam YT, et al. PLoS One. FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats.

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Keywords: Obeticholic Acid (INT-747), 6-ECDCA; UNII-0462Z4S4OZ; OCA; 6-Ethylchenodeoxycholic acid supplier, Farnesoid X Receptor, inhibitors, activators

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