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Farnesoid X Receptor Farnesoid X Receptor

Cat.No.  Name Information
M6201 Tropifexor Tropifexor is a novel and highly potent agonist of farnesoid X receptor (FXR).
M2507 Chenodeoxycholic acid Chenodeoxycholic acid is an epimer of ursodeoxycholic acid, which inhibits the production of cholesterol in the liver and absorption in the intestines.
M2018 GW4064 GW4064 is a selective, non-steroidal agonist of the orphan nuclear receptor FXR with EC50 of 15 nM.
M10940 LY2562175 LY2562175 is an effective and selective FXR agonist EC50 The value is 193 nM.
M10939 Androsterone Androsterone is a metabolite of testosterone that activates the farnidol X receptor (FXR).
M10251 Gly-β-MCA Gly-β-MCA is a potent, stable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor.
M9597 Vonafexor Vonafexor is a farnesoid X receptor agonist.
M9125 Z-Guggulsterone Z-Guggulsterone is a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM).
M9124 DY268 DY268 is a potent FXR antagonist with IC50 of 7.5 nM.
M9111 Nidufexor Nidufexor is a farnesoid X receptor (FXR) agonist.
M9039 Cilofexor Cilofexor is a potent, selective, orally active non-steroidal farnesoid X receptor (FXR) agonist with an EC50 value of 43 nM. It has anti-inflammatory activity and may be studied in primary sclerosing cholangitis (PSC) and non-alcoholic steatohepatitis (NASH).
M6302 Fexaramine Fexaramine is a selective farnesoid X receptor (FXR) agonist with EC50 of 25 nM, with 100-fold increased affinity relative to natural compounds.
M6157 PX-102 PX-102, also known as PX20606, is a FXR agonist.
M5957 Sevelamer HCl Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
M3775 Obeticholic Acid (INT-747) Obeticholic Acid (INT-747) is a potent, orally active, selective farnesoid X receptor (FXR) agonist with an EC50 of 99 nM.May be used in studies related to non-alcoholic steatohepatitis (NASH).
M2165 WAY-362450 (Turofexorate isopropyl) WAY-362450 (Turofexorate isopropyl; XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM.
M50187 ASC-42 ASC-42 is a novel, potentially best-in-class, highly potent and selective non-steroidal FXR agonist that also inhibits the transcription of HBV RNA to hepatitis B surface antigen by inhibiting the transcription of HBV covalent closed-circle DNA (cccDNA) to HBV RNA.
M50186 Linafexor Linafexor is a bile acid receptor (FXR) agonist that may be used in studies related to cholangitis and non-alcoholic steatohepatitis.
M45358 MET-409 MET-409 is an oral non-steroidal bile acid receptor FXR agonist for studies related to inflammatory bowel disease and irritable bowel syndrome.
M42407 FXR agonist 5 FXR agonist 5 is a FXR agonist.




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