| Cat.No. | Name | Information |
|---|---|---|
| M6201 | Tropifexor | Tropifexor is a novel and highly potent agonist of farnesoid X receptor (FXR). |
| M2507 | Chenodeoxycholic acid | Chenodeoxycholic acid is an epimer of ursodeoxycholic acid, which inhibits the production of cholesterol in the liver and absorption in the intestines. |
| M2018 | GW4064 | GW4064 is a selective, non-steroidal agonist of the orphan nuclear receptor FXR with EC50 of 15 nM. |
| M10940 | LY2562175 | LY2562175 is an effective and selective FXR agonist EC50 The value is 193 nM. |
| M10939 | Androsterone | Androsterone is a metabolite of testosterone that activates the farnidol X receptor (FXR). |
| M10251 | Gly-β-MCA | Gly-β-MCA is a potent, stable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor. |
| M9597 | Vonafexor | Vonafexor is a farnesoid X receptor agonist. |
| M9125 | Z-Guggulsterone | Z-Guggulsterone is a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection. |
| M9124 | DY268 | DY268 is a potent FXR antagonist with IC50 of 7.5 nM. DY268 can be used in the study of drug-induced liver injury (DILI). |
| M9111 | Nidufexor | Nidufexor (LMB763) is an orally available farnesoid X receptor (FXR) agonist. |
| M9039 | Cilofexor | Cilofexor is a potent, selective, orally active non-steroidal farnesoid X receptor (FXR) agonist with an EC50 value of 43 nM. It has anti-inflammatory activity and may be studied in primary sclerosing cholangitis (PSC) and non-alcoholic steatohepatitis (NASH). |
| M6302 | Fexaramine | Fexaramine is a selective farnesoid X receptor (FXR) agonist with EC50 of 25 nM, with 100-fold increased affinity relative to natural compounds. |
| M6157 | PX-102 | PX-102, also known as PX20606, is a FXR agonist. |
| M5957 | Sevelamer HCl | Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption. |
| M3775 | Obeticholic Acid (INT-747) | Obeticholic Acid (INT-747) is a potent, orally active, selective farnesoid X receptor (FXR) agonist with an EC50 of 99 nM.May be used in studies related to non-alcoholic steatohepatitis (NASH). |
| M2165 | WAY-362450 (Turofexorate isopropyl) | WAY-362450 (Turofexorate isopropyl; XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM. |
| M55628 | ZLY28 | ZLY28 is a first-in-class intestinal restricted and orally active FXR and FABP1 dual modulator. ZLY28 is also a novel anti-NASH agent. |
| M50187 | ASC-42 | ASC-42 is a novel, potentially best-in-class, highly potent and selective non-steroidal FXR agonist that also inhibits the transcription of HBV RNA to hepatitis B surface antigen by inhibiting the transcription of HBV covalent closed-circle DNA (cccDNA) to HBV RNA. |
| M50186 | Linafexor | Linafexor is a bile acid receptor (FXR) agonist that may be used in studies related to cholangitis and non-alcoholic steatohepatitis. |
| M45358 | MET-409 | MET-409 is an oral non-steroidal bile acid receptor FXR agonist for studies related to inflammatory bowel disease and irritable bowel syndrome. |
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