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Z-Guggulsterone is a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Z-Guggulsterone induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Z-Guggulsterone exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. (Z)-Guggulsterone, a constituent of plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis.
| Molecular Weight | 312.45 |
| Formula | C21H28O2 |
| CAS Number | 39025-23-5 |
| Solubility (25°C) | DMSO 20 mM (with gentle warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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