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Hyodeoxycholic acid

Cat. No. M11414
Hyodeoxycholic acid Structure
Synonym:

HDCA; NSC 60672

Size Price Availability Quantity
100mg USD 65  USD65 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Hyodeoxycholic acid is a secondary bile acid formed by intestinal flora in the small intestine and is an agonist of TGR5 (GPCR19). In CHO cells, the EC50 value is 31.6 µM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 392.58
Formula C24H40O4
CAS Number 83-49-8
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage 4°C , protect from light , dry , sealed
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Keywords: Hyodeoxycholic acid, HDCA; NSC 60672 supplier, Endogenous Metabolite, inhibitors

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