Hyodeoxycholic acid is a secondary bile acid formed by intestinal flora in the small intestine and is an agonist of TGR5 (GPCR19). In CHO cells, the EC50 value is 31.6 µM.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO ≥ 60 mg/mL|
|Storage||4°C , protect from light , dry , sealed|
|Related Endogenous Metabolite Products|
7-ketolithocholic acid (3α -hydroxy-7-oxo-5 β-cholanic acid) is a derivative of cholcholic acid, which can be absorbed to inhibit endogenous bile acid production and bile cholesterol secretion. Cholic acid is also used as a cholic acid derivative of TGR5 regulators.
|Taurodeoxycholate sodium salt
Taurodeoxycholate sodium salt is a bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.
Trichloroacetic acid (TCA) is derived from trichloroethylene (TCE) metabolism. It can be used as an acid decalcifier. Trichloroacetic acid, a metabolite of Trichloroacetic acid, is believed to contribute to its liver cancer effect in mice.
|S-Adenosyl-L-methionine disulfate tosylate
S-adenosyl-l-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the main biomethyl donor synthesized in all mammalian cells, but is most abundant in liver. Ademetionine has anti-inflammatory activity and has been used in studies of chronic liver disease.
Enoxolone (Glycyrrhetin) is a β -aromatic resin alcohol pentacyclic triterpenoid derivative obtained by Glycyrrhetin hydrolysis, with anti-ulcer, anti-inflammatory and anti-proliferation properties.
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