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DCAI, an Inactive Ras, is bound to a GDP and activated by SOS (son of sevenless, among others), which converts it to the active GTP form. DCAI is a known binder to Ras, which inhibits SOS nucleotide exchange, inhibiting Ras activation.
| Molecular Weight | 243.13 |
| Formula | C11H12Cl2N2 |
| CAS Number | 299165-92-7 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] John P O'Bryan. Pharmacological targeting of RAS: Recent success with direct inhibitors
[4] Chengzong Han, et al. Noninvasive three-dimensional cardiac activation imaging on a rabbit model
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