About 30 results found for searched term "CS1" (0.037 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2572 | SMI-4a | Pim |
| TCS PIM-1 4a; 327033-36-3 | ||
| SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modest potent to Pim-2, does not significantly inhibit other serine/threonine- or tyrosine-kinases. | ||
| M2785 | JNK Inhibitor IX (SC202671) | JNK |
| TCS JNK 5a; SC-202671 | ||
| JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. | ||
| M2956 | Pravastatin sodium | HMG-CoA Reductase |
| CS-514 sodium | ||
| Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. | ||
| M3745 | TCS PIM-1 1 | Pim |
| SC 204330 | ||
| TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s > 20,000 nM). | ||
| M3760 | TCS-1102 | OX Receptor |
| TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). | ||
| M3801 | TCS 21311 | JAK |
| TCS 21311 is a potent JAK3 inhibitor with IC50 of 8 nM. | ||
| M7381 | TCS 1105 | Others |
| TCS 1105 is a gABA A α2 benzodiazepine receptor agonist. | ||
| M7382 | TCS 1205 | Others |
| TCS 1205 is a subtype-selective GABA A receptor agonist. | ||
| M7384 | TCS 2314 | Integrin |
| TCS 2314 is a α 4β 1 (VLA-4) antagonist. | ||
| M7385 | TCS 2510 | Prostaglandin Receptor |
| CAY10598; TCS2510 | ||
| TCS 2510 is a selective EP4 agonist. | ||
| M7387 | TCS 5861528 | TRP Channel |
| Chembridge-5861528 | ||
| TCS 5861528 (Chembridge-5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. | ||
| M7397 | TCS PrP Inhibitor 13 | Others |
| TCS PrP Inhibitor 13 is a antiprion agent; inhibits PrP Sc accumulation. | ||
| M8557 | CS1 | Others |
| CS1 is a selective and potent inhibitor of topoisomerase IIα (TopoIIα) that potently inhibits a proliferation of cancer cell lines including MDA-MB-231 and A548 cells, with less toxicity than etoposide. | ||
| M8700 | PCS1055 dihydrochloride | Others |
| PCS1055 is a potent and selective muscarinic M4 acetylcholine receptor competitive antagonist that exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. | ||
| M9412 | IACS-10759 | Others |
| Iacs-10759 is a potent inhibitor of the oxidative phosphorylation complex I (OXPHOS). | ||
| M9464 | Asapiprant | Prostaglandin Receptor |
| S-555739; CS-2811 | ||
| Asapiprant is a potent and selective DP1 receptor antagonist, with a Ki of 0.44 nM. | ||
| M9853 | Brepocitinib P-Tosylate | JAK |
| CS-2860; Brepocitinib；PF-06700841 P-Tosylate | ||
| PF-06700841 (Brepocitinib) tosylate is a dual inhibitor of JAK1 and TYK2, with IC50 values of 17 nM and 23 nM, respectively. | ||
| M10014 | Recombinant Murine M-CSF Protein (HEK 293, C-His) | Recombinant Proteins |
| CSF-1; MGI-IM | ||
| Recombinant Murine M-CSF Protein (HEK 293) is a powerful hematopoietic factor produced by lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. | ||
| M10326 | Zuranolone | GABA Receptor |
| SAGE-217; CS-2797; BIIB125 | ||
| Zuranolone also known as SAGE-217, is a potent GABAA receptor agonist with EC50 values of 296 nM and 163 nM for α1β2γ2 and α4β3δ GABAA receptors. | ||
| M10479 | Esaxerenone (CS-3150) | Mineralocorticoid Receptor |
| CS-3150; XL-550 | ||
| Esaxerenone (CS-3150) is a highly potent and selective non-steroidal mineralocorticoid receptor antagonist. | ||
| M10513 | MA-0204 | PPAR |
| CS-2841; MA0204 | ||
| MA-0204 is a highly potent and selective PPARδ modulator (PPARδ EC50 = 0.4 nM; PPARα, EC50 = 6,660 nM) that upregulates the expression of FAO genes in human renal proximal tubule cells, resulting in increased mitochondrial fatty acid oxidation. | ||
| M10592 | Recombinant Human M-CSF (CHO) | Recombinant Proteins |
| Recombinant Human Macrophage Colony-stimulating Factor; CSF-1; rHM-CSF | ||
| Human M-CSF protein (CHO) is a hematopoietic growth factor with multiple glycoylation sites, which can affect the survival and function of macrophages and has antitumor activity. It was expressed by CHO cells. | ||
| M10738 | IACS-13909 | Phosphatase |
| IACS-13909 is a potent selective, orally active SHP2 allosteric inhibitor IC50 for 15.7 nM,Kd 32 nM. IACS-13909 is more selective for SHP2 than other phosphatase, including SHP1. IACS-13909 inhibits the signaling of the receptor tyrosine kinase (RTK)/MAPK pathway and has an anticancer effect. | ||
| M10769 | CS-2671 | Others |
| TASP0415914 is an effective and orally active PI3Kγ inhibitor,IC50 29 nM. | ||
| M10945 | Chiauranib | VEGFR/PDGFR |
| CS2164 | ||
| Chiauranib (CS2164) is a first-in-class orally active multi-target inhibitor of tumor angiogenesis.Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B and chronic inflammation-related kinase CSF-1R. Chiauranib has strong anticancer activity. | ||
| M11268 | LSZ-102 | Estrogen Receptor |
| CS-2791 | ||
| Lsz-102 is a potent, oral bioeffective selective estrogen receptor inhibitor with an IC50 value of 0.2 nM. | ||
| M11283 | Inolitazone dihydrochloride | PPAR |
| Efatutazone dihydrochloride; CS-7017 dihydrochloride; RS5444 dihydrochloride | ||
| Inolitazone dihydrochloride (Efatutazone dihydrochloride) is a PPARγ agonist with high affinity, activity dependent on PPARγ, inhibiting growth, IC50 is 0.8 nM. | ||
| M11342 | LCS-1 | SOD |
| LCS1 | ||
| LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibited SOD1 activity with IC50 value of 1.07 μM. LCS-1 induces early and late apoptosis in multiple myeloma cells (MM.1S). | ||
| M11449 | AG-024322 | COX |
| CS-1092 | ||
| Ag-024322 is a potent ATP-competitive pan-CDK inhibitor that inhibits THE Ki values of CDK1, CDK2, and CDK4 in the 1-3 nM range. Ag-024322 showed broad spectrum antitumor activity and clear target regulation in vivo. Ag-024322 induced apoptosis. | ||
| M11485 | Recombinant Mouse GM-CSF Protein (E. coli) | Recombinant Proteins |
| Granulocyte Macrophage Colony Stimulating Factor; CSF-2; MGI-1GM | ||
| Expression system: E. coli Bioactivity: ED50 < 5.0 pg/ mL, measured in cell proliferation assay of mouse FDC-P1 cells, corresponding specific activity > 2.0 × 108 units/mg. | ||
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