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LCS-1

Cat. No. M11342
LCS-1  Structure
Synonym:

LCS1

Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 90  USD90 In stock
25mg USD 195  USD195 In stock
50mg USD 340  USD340 In stock
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Quality Control & Documentation
Biological Activity

LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibited SOD1 activity with IC50 value of 1.07 μM. LCS-1 induces early and late apoptosis in multiple myeloma cells (MM.1S).

Chemical Information
Molecular Weight 255.1
Formula C11H8Cl2N2O
CAS Number 41931-13-9
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Anas Ahmad, et al. ACS Appl Bio Mater. Aminocellulose-Grafted Polymeric Nanoparticles for Selective Targeting of CHEK2-Deficient Colorectal Cancer

[2] Li-Han Chen, et al. J Cachexia Sarcopenia Muscle. Probiotic supplementation attenuates age-related sarcopenia via the gut-muscle axis in SAMP8 mice

[3] Alessia Centonze, et al. Nature. Heterotypic cell-cell communication regulates glandular stem cell multipotency

[4] Dietmar Steverding, et al. Drug Res (Stuttg). Cytotoxic Activity of LCS-1 is not Only due to Inhibition of SOD1

[5] Anuradha Gupta, et al. Biomacromolecules. Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS-1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells

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Keywords: LCS-1 , LCS1 supplier, SOD, inhibitors, activators


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