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ATN-224 is an orally active superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity with an IC50 of 17.5±3.7 nM on endothelial cells.
| Molecular Weight | 432.56 |
| Formula | C10H28MoN2O2S4 |
| CAS Number | 649749-10-0 |
| Solubility (25°C) | DMSO > 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Annu Aggarwal, et al. Curr Opin Neurol. Wilson disease
[2] Caitlin Mulligan, et al. Neurol Clin. Wilson Disease: An Overview and Approach to Management
[3] Anna Członkowska, et al. Nat Rev Dis Primers. Wilson disease
[4] Annu Aggarwal, et al. Tremor Other Hyperkinet Mov (N Y). Advances in Treatment of Wilson Disease
[5] Delphine Denoyer, et al. Met Ions Life Sci. Copper Complexes in Cancer Therapy
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| LCS-1
LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibited SOD1 activity with IC50 value of 1.07 μM. LCS-1 induces early and late apoptosis in multiple myeloma cells (MM.1S). |
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