ATN-224 is an orally active superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity with an IC50 of 17.5±3.7 nM on endothelial cells.
| Molecular Weight | 432.56 |
| Formula | C10H28MoN2O2S4 |
| CAS Number | 649749-10-0 |
| Solubility (25°C) | DMSO > 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Annu Aggarwal, et al. Curr Opin Neurol. Wilson disease
[2] Caitlin Mulligan, et al. Neurol Clin. Wilson Disease: An Overview and Approach to Management
[3] Anna Członkowska, et al. Nat Rev Dis Primers. Wilson disease
[4] Annu Aggarwal, et al. Tremor Other Hyperkinet Mov (N Y). Advances in Treatment of Wilson Disease
[5] Delphine Denoyer, et al. Met Ions Life Sci. Copper Complexes in Cancer Therapy
| Related SOD Products |
|---|
| Antioxidant peptide A
Antioxidant peptide A is a short peptide, which contains alternative aromatic or sulfur-containing amino acid. |
| LCS-1
LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibited SOD1 activity with IC50 value of 1.07 μM. LCS-1 induces early and late apoptosis in multiple myeloma cells (MM.1S). |
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