About 30 results found for searched term "BMS-3" (0.009 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1657 | Atazanavir Sulfate | HIV Protease |
| BMS-232632, Reyataz, CGP-73547 | ||
| Atazanavir sulfate (BMS-232632, Reyataz) is an azapeptide inhibitor of HIV-1 protease. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. | ||
| M1681 | BMS-707035 | Integrase |
| BMS707035 | ||
| BMS-707035 is an HIV-1 integrase (IN) inhibitor. HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic. | ||
| M1682 | BMS-777607 | c-Met |
| BMS 817378; CAS# 1025720-94-8 | ||
| BMS-777607 is a selective and potent small-molecule met kinase inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively. | ||
| M1683 | BMS 794833 | c-Met |
| BMS-794833 is a potent ATP competitive Met/VEGFR-2 kinase inhibitor. | ||
| M1701 | Dasatinib | Src-bcr-Abl |
| BMS-354825 | ||
| Dasatinib (BMS-354825) is a small molecule inhibitor of both the SRC and BCR/ABL tyrosine kinases, with IC50's for the isolated kinases of 0.55 and 3.0 nM, respectively. | ||
| M1757 | XL-184 | c-Met |
| Cabozantinib, BMS-907351，Cabometyx | ||
| XL184 is a small molecule inhibits multiple receptor tyrosine kinases, specifically MET and VEGFR2 with IC50 values of 0.035 and 1.8 nM for VEGFR2 and Met respectively. | ||
| M1947 | BMS-708163 | Gamma-secretase/Beta-secretase |
| Avagacestat | ||
| BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM). | ||
| M1957 | BMS-536924 | IGF-1R |
| Bms-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50 of 100 nM and 73 nM, respectively. It also showed moderate inhibitory activity against Mek, Fak and Lck, but almost no inhibitory activity against Akt1 and MAPK1/2. | ||
| M2065 | SNS-032 | CDK |
| BMS-387032 | ||
| SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK 9, 2 and 7 with IC50 values of 4, 38 and 62 nM respectively. | ||
| M9165 | Rimegepant | CGRP Receptor |
| BMS-927711; BHV-3000 | ||
| Rimegepant, also known as BMS-927711, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist with a Ki value of 0.027 nM. | ||
| M2208 | Lomitapide | Others |
| AEGR-733, BMS-201038 | ||
| Lomitapide (AEGR-733, BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM. | ||
| M2254 | Gatifloxacin | Antibiotic |
| Gatiflo; AM-1155; BMS-206584; PD135432 | ||
| Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family. | ||
| M2336 | BMS-345541 hydrochloride | IκB/IKK |
| BMS-345541 hcl | ||
| BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IC50 values of 0.3 μM and 4 μM for IKK-2 and IKK-1 respectively). | ||
| M2340 | Asunaprevir | HCV Protease |
| BMS-650032 | ||
| Asunaprevir (BMS-650032) is a novel inhibitor of the hepatitis C virus enzyme serine protease NS3. | ||
| M2462 | BMS-345541 | IκB/IKK |
| BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively. | ||
| M2463 | BMS-663068 | HIV Protease |
| Fostemsavir | ||
| BMS-663068 is a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells with EC50 of < 10 nM. | ||
| M2465 | BMS-833923 | Smo |
| XL139 | ||
| BMS-833923 is an orally bioavailable Smoothened antagonist. | ||
| M2466 | BMS-911543 | JAK |
| BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. | ||
| M3485 | BMS-378806 | HIV Protease |
| BMS 806 | ||
| BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus. | ||
| M3641 | XL413 | CDK |
| BMS-863233 | ||
| XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM. | ||
| M3762 | BMS303141 | Others |
| BMS303141 is a potent ATP-citrate lyase (ACL) inhibitor with IC50 value of 0.13 uM. | ||
| M5125 | BMS-687453 | PPAR |
| Bms-687453 is an effective and selective PPARα agonist with EC50 and IC50 of 10 nM and 260 nM for human PPARα, respectively. The EC50 and IC50 values were 4100 nM and >15000 nM, respectively. | ||
| M5427 | Atazanavir | HIV Protease |
| BMS-232632; Latazanavir; Zrivada; Reyataz | ||
| Atazanavir (BMS-232632) is an azapeptide and HIV-protease inhibitor. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. | ||
| M5552 | Dasatinib HCl | Src-bcr-Abl |
| BMS 354825 hydrochloride | ||
| Dasatinib(BMS-354825) hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of ＜1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM. | ||
| M5553 | Dasatinib Monohydrate | Src-bcr-Abl |
| BMS-354825 Monohydrate | ||
| Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively. | ||
| M5751 | Lomitapide Mesylate | Others |
| AEGR-733 mesylate; BMS-201038 mesylate | ||
| Lomitapide Mesylate is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia. | ||
| M6100 | Nivolumab | PD-1/PD-L1 |
| BMS-936558, ONO-4538, MDX-1106；Opdivo | ||
| Nivolumab (nabumab) is a fully humanized IgG4 monoclonal antibody against PD-1. It has immune checkpoint inhibitory activity and antitumor activity; MW: 143.597 KD.(for human-derived mice). | ||
| M6104 | Ipilimumab | Checkpoint |
| MDX-010, BMS-734016；Yervoy | ||
| Ipilimumab (MDX-010, BMS-734016) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. | ||
| M6144 | BMS-3 | LIM Kinase |
| BMS-3 is a potent inhibitor of LIMK1.LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression. | ||
| M6249 | BMS-813160 | CCR |
| BMS813160 | ||
| BMS-813160 is the first dual CCR2/CCR5 antagonist. BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively. | ||
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