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Atazanavir

Cat. No. M5427
Atazanavir Structure
Synonym:

Latazanavir, Zrivada, Reyataz, BMS-232632

Size Price Availability Quantity
10mg USD 90  USD100 In stock
50mg USD 225  USD250 In stock
100mg USD 315  USD350 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 704.86
Formula C38H52N6O7
CAS Number 198904-31-3
Purity >98%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

Atazanavir exposure is effective during pregnancy regardless of tenofovir use.
Colbers A, et al. Antivir Ther. 2015;20(1):57-64. PMID: 24992294.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Atazanavir, Latazanavir, Zrivada, Reyataz, BMS-232632 supplier, HIV Protease, inhibitors

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