About 28 results found for searched term "5-HT2 agonist-1" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41735 | 5-HT2 agonist-1 free base | 5-HT Receptor |
| 5-HT2 agonist-1 free base is a 5-HT2A & 5-HT2B & 5-HT2C agonist, with IC50s of 10 nM, 8.3, and 1.6 nM respectively. | ||
| M41736 | 5-HT2A&5-HT2C agonist-1 | 5-HT Receptor |
| 5-HT2A&5-HT2C agonist-1 is a 5-HT2A & 5-HT2C agonist, with IC50s of 196 nM and 0.9 nM respectively. | ||
| M41738 | 5-HT2 agonist-1 | 5-HT Receptor |
| 5-HT2 agonist-1 is a 5-HT2A & 5-HT2B & 5-HT2C agonist, with IC50s of 10 nM, 8.3, and 1.6 nM respectively. | ||
| M58155 | 5-HT2B antagonist-1 | 5-HT Receptor |
| 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. | ||
| M2266 | Pizotifen malate | 5-HT Receptor |
| Sandomigran, pizotyline | ||
| Pizotifen malate is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site. | ||
| M3363 | RS-127445 | 5-HT Receptor |
| MT500 | ||
| RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors. | ||
| M3997 | Nuciferine | 5-HT Receptor |
| Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM). Nuciferine possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. | ||
| M5848 | Paliperidone | Dopamine Receptor |
| 9-hydroxyrisperidone | ||
| Paliperidone, the main active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. | ||
| M5884 | Pizotifen | 5-HT Receptor |
| Pizotyline; BC-105 | ||
| Pizotifen (Pizotyline) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site. | ||
| M13869 | Ketanserin tartrate | 5-HT Receptor |
| R41468 tartrate | ||
| Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM). | ||
| M20535 | Chlorpromazine | Dopamine Receptor |
| Chlorpromazine is an orally active, blood-brain barrier-transparent D2 dopamine receptors and 5-HT2A antagonist. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM). | ||
| M27904 | Lumateperone tosylate | 5-HT Receptor |
| ITI-007 tosylate | ||
| Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia. | ||
| M28018 | Brilaroxazine | Dopamine Receptor |
| RP5063 | ||
| Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki=1.5 nM) and 5-HT2A (Ki=2.5 nM), and has antagonist activity at 5-HT2B (Ki=0.19 nM), and 5-HT7 (Ki=2.7 nM) receptors. | ||
| M28096 | S1RA hydrochloride | Sigma Receptor |
| E-52862 hydrochloride | ||
| S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization. | ||
| M28951 | RS-102221 | 5-HT Receptor |
| RS-102221 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats. | ||
| M28976 | RS-102221 hydrochloride | 5-HT Receptor |
| RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats. | ||
| M29070 | Methiothepin maleate | 5-HT Receptor |
| Metitepine maleate; Ro-8-6837 maleate | ||
| Methiothepin maleate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C). | ||
| M29092 | RS-127445 | 5-HT Receptor |
| RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. | ||
| M29891 | Lumateperone | Dopamine Receptor |
| ITI-007 | ||
| Lumateperone (ITI-007) is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia. | ||
| M30283 | Cinanserin hydrochloride | 5-HT Receptor |
| SQ 10643 | ||
| Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. | ||
| M30370 | (S)-Mirtazapine | 5-HT Receptor |
| (S)-Org3770; (S)-6-Azamianserin | ||
| (S)-Mirtazapine ((S)-Org3770) is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2. | ||
| M30773 | SCH-23390 maleate | Dopamine Receptor |
| R-(+)-SCH-23390 maleate | ||
| SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM. | ||
| M30957 | Piromelatine | Melatonin Receptor |
| Neu-P11 | ||
| Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities. | ||
| M41733 | AC-90179 | 5-HT Receptor |
| AC-90179 is a selective 5-HT2A receptor inverse agonist (Ki = 2.1 nM) and 5-HT2C antagonist, a potential antipsychotic compound. | ||
| M41740 | 5-HT2C agonist-3 free base | 5-HT Receptor |
| 5-HT2C agonist-3 ((+)-19) free base is a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM). | ||
| M41743 | 5-HT2C agonist-3 | 5-HT Receptor |
| 5-HT2C agonist-3 ((+)-19) is a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM). | ||
| M41755 | MRS7925 | 5-HT Receptor |
| MRS7925 is a 5-HT2BR antagonist (Ki: 17 nM). | ||
| M56089 | FR260010 free base | 5-HT Receptor |
| FR260010 free base is a selective 5-HT2C receptor antagonist, with a Ki value of 1.1 nM. | ||
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