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TCS 401

Cat. No. M14498
TCS 401 Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 306.72
Formula
CAS Number 243966-09-8
Purity >99%
Solubility 0.1 M NaOH 6.67 mg/mL (ultrasonic and adjust pH to 9 with NaOH)
Storage 2-8°C, dry, sealed
References

[1] Mahdi Al Dhafiri, et al. Topical Steroid Damaged Face: A Cross-Sectional Study from Saudi Arabia

[2] Michael Kreiberg, et al. Psychological stress in long-term testicular cancer survivors: a Danish nationwide cohort study

[3] Tanja Makazlieva, et al. Prognostic factors in thyroid carcinomas: a 17-year outcome study

[4] F Seyed Sadjadi, et al. Bleaching effects of massecuite on some properties of crystallized sugar beet and milk chocolate bars produced

[5] Zhao-dong Du, et al. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells

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