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L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors.
| Molecular Weight | 363.28 |
| Formula | C18H20Cl2N4 |
| CAS Number | 1173023-36-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 32.26 mg/mL (ultrasonic) 0.1 M HCL : 25 mg/mL (ultrasonic and adjust pH to 3 with HCl) |
| Storage | 4°C, dry, sealed |
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