Certificate of Analysis
| Product Name: | L-745870 hydrochloride |
| Catalog Number: | M27880 |
| CAS Number: | 1173023-36-3 |
Physical and Chemical Properties
| Formula: | C18H20Cl2N4 |
| Molecular Weight: | 363.28 |
| Form: | Solid |
| Solubility: | DMSO 32.26 mg/mL (ultrasonic) 0.1 M HCL : 25 mg/mL (ultrasonic and adjust pH to 3 with HCl) |
| Storage: | 4°C, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |