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(E/Z)-BCI

Cat. No. M20734

All AbMole products are for research use only, cannot be used for human consumption.

(E/Z)-BCI Structure
Synonym:

BCI, NSC 150117

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Quality Control & Documentation
Biological Activity

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

Chemical Information
Molecular Weight 317.42
Formula C22H23NO
CAS Number 15982-84-0
Solubility (25°C) DMSO 63 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hasan Onur Caglar, et al. Gene. Identification of upregulated genes in glioblastoma and glioblastoma cancer stem cells using bioinformatics analysis

[2] Boya Zhang, et al. Cell Death Dis. DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling

[3] Nicole E James, et al. Oncotarget. Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes

[4] Fan Zhang, et al. Inflammation. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway

[5] Qi-Nian Wu, et al. Cancer Lett. Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance

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  Catalog
Abmole Inhibitor Catalog




Keywords: (E/Z)-BCI, BCI, NSC 150117 supplier, Phosphatase, inhibitors, activators

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