| Cat.No. | Name | Information |
|---|---|---|
| M1658 | Axitinib | Axitinib (AG013736) inhibits multiple targets including VEGFR, PDGFR and cKit. |
| M2194 | SU5402 | SU5402 is a potent and selective VEGFR and FGFR inhibitor with IC50 values of 0.02, 0.03, 0.51 and > 100 μM for VEGFR2, FGFR1, PDGFRβ and EGFR respectively. |
| M1838 | Masitinib | Masitinib is a tyrosine kinase inhibitor targeting stem cell factor receptor (c-kit) and platelet-derived growth factor (PDGF) receptor. |
| M1956 | Apatinib mesylate | Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor of VEGFR2 with an IC50 of 2.43 nM. |
| M1841 | Lenvatinib | Lenvatinib (E7080) is a potent inhibitor of multiple tyrosine kinases, including VEGF-R3 tyrosine kinase (IC50=5.2 nM) and VEGF-R2 tyrosine kinase (IC50=4.0 nM). |
| M1669 | Regorafenib | Regorafenib (BAY 73-4506) is a novel oral multikinase inhibitor of c-KIT, VEGFR2, B-Raf with IC50s of 17, 40 and 69 nM respectively. |
| M1827 | Sorafenib Tosylate | Sorafenib (BAY 43-9006) Tosylate is an orally active multikinase inhibitor of tyrosine protein kinases VEGFR/PDGFR and RAF/MEK/ERK with IC50 values of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. |
| M1964 | Vandetanib | Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase (IC50=40 nM). Vandetanib also inhibited VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM). |
| M5005 | Regorafenib Monohydrate | Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. |
| M1882 | Vatalanib dihydrochloride | Vatalanib is a selective small molecule protein kinase inhibitor of VEGF receptors 1-3 with IC50 of 37 nM. |
| M20586 | ZD-4190 | ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively. |
| M20360 | WAY-302159 | WAY-302159 is a novel VEGFR-2 inhibitor. |
| M20358 | WAY-340935 | WAY-340935 is a VEGFR2 kinase inhibitor. |
| M20201 | WAY-607500 | WAY-607500 is a VEGFR inhibitor. |
| M20170 | WAY-357919 | WAY-357919 is a inhibitor of vascular endothelial growth factor receptor-2. |
| M20107 | WAY-325185 | WAY-325185 altering the lifespan of a eukaryotic organism |
| M20062 | WAY-297629 | WAY-297629 is a VEGFR2 inhibitor. |
| M20044 | WAY-271147 | WAY-271147 is a VEGFR inhibitor |
| M20043 | WAY-271146 | WAY-271146 is a VEGFR inhibitor |
| M20021 | GI-555736 | GI-555736 altering the lifespan of a eukaryotic organism |
| M20019 | CL-230482 | CL-230482 is a PDGFR inhibitor. |
| M20016 | AY-20590 | AY-20590 is a inhibitor of Mcl-1 (for the treatment of cancer and other diseases). |
| M14922 | TG 100801 | TG 100801 is a prodrug that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. |
| M14921 | Telatinib mesylate | Telatinib mesylate (Bay 57-9352 mesylate) is a potent and orally active VEGFR2, VEGFR3, PDGFα, and c-Kit inhibitor with IC50s of 6 nM, 4 nM, 15 nM and 1 nM, respectively. |
| M8512 | EG00229 | EG00229 is an antagonist of the VEGF-A receptor neuropilin 1 (NRP1), which decreases viability of A549 lung carcinoma cells. |
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