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TG 100801

Cat. No. M14922

All AbMole products are for research use only, cannot be used for human consumption.

TG 100801 Structure

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Quality Control & Documentation
Biological Activity

TG 100801 is a prodrug that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.

Chemical Information
Molecular Weight 580.08
CAS Number 867331-82-6
Solubility (25°C) DMSO 5.56 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shalini Sharma, et al. An anti-inflammatory role of VEGFR2/Src kinase inhibitor in herpes simplex virus 1-induced immunopathology

[2] Shaker A Mousa, et al. Current status of vascular endothelial growth factor inhibition in age-related macular degeneration

[3] John Doukas, et al. Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema

[4] Moorthy S S Palanki, et al. Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degener䲧璵Ỵ璶

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  Catalog
Abmole Inhibitor Catalog




Keywords: TG 100801 supplier, VEGFR/PDGFR, inhibitors, activators

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