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EG00229

Cat. No. M8512

All AbMole products are for research use only, cannot be used for human consumption.

EG00229 Structure
Synonym:

EG-00229

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Quality Control & Documentation
Biological Activity

EG00229 is an antagonist of the VEGF-A receptor neuropilin 1 (NRP1), which decreases viability of A549 lung carcinoma cells. EG00229 impairs VEGFA induced migration of HUV-EC-C endothelial cells.

Chemical Information
Molecular Weight 497.57
Formula C17H19N7O5S3
CAS Number 1018927-63-3
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lele Cong, et al. Effect of EG00229 on Radiation Resistance of Lung Adenocarcinoma Cells

[2] Methus Klaewkla, et al. Molecular basis of the new COVID-19 target neuropilin-1 in complex with SARS-CoV-2 S1 C-end rule peptide and small-molecule antagonists

[3] Aubin Moutal, et al. SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia

[4] Krishnendu Pal, et al. Synchronous inhibition of mTOR and VEGF/NRP1 axis impedes tumor growth and metastasis in renal cancer

[5] Jeremy T Miyauchi, et al. Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression

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  Catalog
Abmole Inhibitor Catalog




Keywords: EG00229, EG-00229 supplier, VEGFR/PDGFR, inhibitors, activators

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