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Cat. No. M2194
SU5402 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 70  USD70 In stock
10mg USD 95  USD95 In stock
50mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

SU5402 is a potent and selective small molecular vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor. SU5402 inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo.

Product Citations
Customer Product Validations & Biological Datas
Source Stem Cell Reports (2017). SU5402, Figure1 . (AbMole Bioscience)
Cell Lines The mouse ESC lines J1 (ATCC SCRC-1010), CCE, and Jmjd2c KO
Concentrations 10 μM
Incubation Time
Results FGFR inhibition (FGFRi) by SU5402 had little effect compared with LIF (Figure 1A). A two-inhibitor combination (PD0325901 and CHIR99021) and a threeinhibitor combination (PD0325901, CHIR99021, and SU5402) produced robust AP staining of ESCs with a compact colony morphology.
Protocol (for reference only)
Cell Experiment
Cell lines KMS11, UTMC-2, LP1, OPM1, OPM2, KHM11, JJN3, RPMI8226, EJM, K620, H929, U266 and OCI-My5 cell lines
Preparation method KMS11 (provided by MasayoshiNamba), UTMC-2, LP1, OPM1, OPM2, KHM11, JJN3, RPMI8226, EJM, K620, H929 (provided by Leif Bergsagel), U266 and OCI-My5 (provided by Robert Hawley) were grown in Iscove’s modified Dulbecco’s medium (IMDM) supplemented with 10% fetal calf serum (FCS) and 1% Gibco antimycotic/antibiotic (Invitrogen Canada, Ontario, Canada). For proliferation assays, cells were washed and plated in triplicate in IMDM plus 5% FCS and incubated with various concentrations of SU5402. Cells were then analysed by MTT [3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide] assay (Boehringer Mannheim, Mannheim, Germany) according to the manufacturer’s protocol.
Concentrations 0, 2,10µM
Incubation time 48 h
Animal Experiment
Animal models Spinal cords lesions of zebrafish
Formulation DMSO
Dosages 1 μl of 5 μg/μl
Administration injection
Chemical Information
Molecular Weight 296.32
Formula C17H16N2O3
CAS Number 215543-92-3
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Paul Kachel, et al. BMC Cancer. Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue

[2] Bojesen KB, et al. J Biol Chem. Nectin-1 binds and signals through the fibroblast growth factor receptor.

[3] Zhu X, et al. Gene. Characterization and expressional analysis of Dleu7 during Xenopus tropicalis embryogenesis.

[4] Hirabayashi M, et al. Transgenic Res. A retrospective analysis of germline competence in rat embryonic stem cell lines.

[5] Tanaka Y, et al. Nature. FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.

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Keywords: SU5402 supplier, VEGFR/PDGFR, inhibitors, activators

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