| Cat.No. | Name | Information |
|---|---|---|
| M1781 | Adezmapimod (SB203580) | Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. |
| M2062 | SB 202190 | SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively. |
| M1675 | BIRB796 | BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK with Kd of 100pM. |
| M1556 | Hesperetin | Hesperetin is a potent and broad-spectrum inhibitor against human UGT activity. |
| M11380 | Gossypetin | Gossypetin, a hexahydroxylated flavonoid, is an effective inhibitor of MKK3 and MKK6, which can strongly weaken the mKK3/6-P38 signal transduction pathway and has a variety of pharmacological activities, including antioxidant, antibacterial and anticancer activities. |
| M10551 | Gypenoside L | Gypenoside L activates p38 and ERK MAPK pathways and NF-κB pathway to induce senescence, it is a saponin that can be found in Gynostemma pentaphyllum. |
| M9229 | GS-444217 | GS-444217 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87±0.85 nM. |
| M9160 | BMS-582949 | BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13nM. |
| M9013 | R1487 Hydrochloride | R1487 Hydrochloride is an orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. |
| M8991 | Dilmapimod | Dilmapimod (also known as SB-681323 and GW-681323) is a p38 MAPK inhibitor that potentially suppresses inflammation in COPD. |
| M8910 | Pamapimod | Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor, inhibited p38alpha and p38beta enzymatic activity, with IC50 values of 0.014 +/- 0.002 and 0.48 +/- 0.04 microM, respectively. |
| M7582 | SB 239063 | SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. |
| M7558 | SD-06 | SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). IC50 value: 170 nM Target: p38MAPK |
| M7545 | SKF-86002 | SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes. |
| M7360 | TC ASK 10 | TC ASK 10 is a potent and selective ASK1 inhibitor; orally bioavailable. |
| M7008 | Muramyl Dipeptide | Muramyl Dipeptide is a bacterial peptidoglycan fragment that activates NOD2 receptors. Muramyl Dipeptide induces polarization of proinflammatory Ly6Chigh into Ly6Clow patrolling monocytes. |
| M6286 | Selonsertib | GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. |
| M6146 | TA-02 | TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. TA-02 especially inhibits TGFBR-2. |
| M5873 | Pexmetinib (ARRY-614) | Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1. |
| M4707 | Kaempferol-3-O-glucorhamnoside | Kaempferol-3-o-glucorhamnoside is a flavonoid derived from Thesium chinense Turcz, which inhibits inflammatory responses through MAPK and NF-κB pathways in vitro and in vivo. |
| M4509 | Asiatic-acid | Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing. |
| M4480 | Bakuchiol | Bakuchiol is a phytoestrogens from psoralea seeds that have anti-tumor and other effects. |
| M4474 | Cornuside | Cornuside is a terpene glycoside isolated from the fruit of Cornus officinalis Sieb. Et Zucc. Cornus officinalis is a traditional Oriental medicine that can be used to study inflammatory diseases and promote blood circulation. |
| M4415 | Sesamolin | Sesaminol can be isolated from Justicia Orbiculata and has antioxidant activity. Sesaminol inhibits lipid peroxidation and has neuroprotective effect. Sesaminol inhibits MAPK cascade by inhibiting phosphorylation of JNK, P38 MAPKs, and Caspase-3. |
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