| Cat.No. | Name | Information |
|---|---|---|
| M1781 | Adezmapimod (SB203580) | Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. |
| M2062 | SB 202190 | SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively. |
| M1675 | BIRB796 | BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK with Kd of 100pM. |
| M1556 | Hesperetin | Hesperetin is a potent and broad-spectrum inhibitor against human UGT activity. |
| M21038 | MK2 Inhibitor III | MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM. |
| M8991 | Dilmapimod | Dilmapimod (also known as SB-681323 and GW-681323) is a p38 MAPK inhibitor that potentially suppresses inflammation in COPD. |
| M3751 | Losmapimod | Losmapimod (GW856553) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. |
| M14176 | MAPK13-IN-1 | MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM. |
| M14175 | Esculin | Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark. |
| M14164 | GNE-3511 | GNE-3511 is an orally active, bioavailable and brain-permeable dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM.GNE-3511 can be used in studies related to neurodegenerative diseases. |
| M11380 | Gossypetin | Gossypetin, a hexahydroxylated flavonoid, is an effective inhibitor of MKK3 and MKK6, which can strongly weaken the mKK3/6-P38 signal transduction pathway and has a variety of pharmacological activities, including antioxidant, antibacterial and anticancer activities. |
| M10551 | Gypenoside L | Gypenoside L activates p38 and ERK MAPK pathways and NF-κB pathway to induce senescence, it is a saponin that can be found in Gynostemma pentaphyllum. |
| M9229 | GS-444217 | GS-444217 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87±0.85 nM. |
| M9160 | BMS-582949 | BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13nM. |
| M9013 | R1487 Hydrochloride | R1487 Hydrochloride is an orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. |
| M8910 | Pamapimod | Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor, inhibited p38alpha and p38beta enzymatic activity, with IC50 values of 0.014 +/- 0.002 and 0.48 +/- 0.04 microM, respectively. |
| M7582 | SB 239063 | SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. |
| M7558 | SD-06 | SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). IC50 value: 170 nM Target: p38MAPK |
| M7545 | SKF-86002 | SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes. |
| M7360 | TC ASK 10 | TC ASK 10 is a potent and selective ASK1 inhibitor; orally bioavailable. |
| M7008 | Muramyl Dipeptide | Muramyl Dipeptide is a bacterial peptidoglycan fragment that activates NOD2 receptors. Muramyl Dipeptide induces polarization of proinflammatory Ly6Chigh into Ly6Clow patrolling monocytes. |
| M6286 | Selonsertib | GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. |
| M6146 | TA-02 | TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. TA-02 especially inhibits TGFBR-2. |
| M5873 | Pexmetinib (ARRY-614) | Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1. |
| M4707 | Kaempferol-3-O-glucorhamnoside | Kaempferol-3-o-glucorhamnoside is a flavonoid derived from Thesium chinense Turcz, which inhibits inflammatory responses through MAPK and NF-κB pathways in vitro and in vivo. |
| M4509 | Asiatic-acid | Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing. |
| M4480 | Bakuchiol | Bakuchiol is a phytoestrogens from psoralea seeds that have anti-tumor and other effects. |
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