p38 MAPK P38 mitogen-activated protein kinases

Cat.No.	Name	Information
M1781	Adezmapimod (SB203580)	Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM.
M2062	SB 202190	SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively.
M1675	BIRB796	BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK with Kd of 100pM.
M8910	Pamapimod	Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor, inhibited p38alpha and p38beta enzymatic activity, with IC50 values of 0.014 +/- 0.002 and 0.48 +/- 0.04 microM, respectively.
M7582	SB 239063	SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580.
M7558	SD-06	SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). IC50 value: 170 nM Target: p38MAPK
M7545	SKF-86002	SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes.
M7360	TC ASK 10	TC ASK 10 is a potent and selective ASK1 inhibitor; orally bioavailable.
M7008	Muramyl Dipeptide	Muramyl Dipeptide is a activates NOD2 receptors.
M6286	Selonsertib	GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
M6146	TA 02	TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.
M5873	Pexmetinib (ARRY-614)	Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.
M4707	Kaempferol-3-O-glucorhamnoside	Kaempferol-3-o-glucorhamnoside is a flavonoid derived from Thesium chinense Turcz, which inhibits inflammatory responses through MAPK and NF-κB pathways in vitro and in vivo.
M4509	Asiatic-acid	Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.
M4480	Bakuchiol	Bakuchiol is a phytoestrogens from psoralea seeds that have anti-tumor and other effects.
M4474	Cornuside-I	Cornuside is a terpene glycoside isolated from the fruit of Cornus officinalis Sieb. Et Zucc. Cornus officinalis is a traditional Oriental medicine that can be used to study inflammatory diseases and promote blood circulation.
M4415	Sesamolin	Sesaminol can be isolated from Justicia Orbiculata and has antioxidant activity. Sesaminol inhibits lipid peroxidation and has neuroprotective effect. Sesaminol inhibits MAPK cascade by inhibiting phosphorylation of JNK, P38 MAPKs, and Caspase-3.
M3751	Losmapimod	Losmapimod (GW856553) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
M3294	VX-745	VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
M3048	TAK-715	TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
M3011	Skepinone-L	Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM.
M2583	PD 169316	PD 169316 is a cell-permeable, potent and selective p38 MAP kinase inhibitor that indirectly activates proteasome activity and has antiviral activity against Enterovirus71 with an IC50 value of 89 nM.
M2318	LY2228820	LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM.

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p38 MAPK P38 mitogen-activated protein kinases

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