| Cat.No. | Name | Information |
|---|---|---|
| M1781 | Adezmapimod (SB203580) | Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. |
| M2062 | SB 202190 | SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively. |
| M1675 | BIRB796 | BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK with Kd of 100pM. |
| M1556 | Hesperetin | Hesperetin is a potent and broad-spectrum inhibitor against human UGT activity. |
| M3751 | Losmapimod | Losmapimod (GW856553) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. |
| M3294 | VX-745 | VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ. |
| M3048 | TAK-715 | TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. |
| M3011 | Skepinone-L | Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM. |
| M2583 | PD 169316 | PD 169316 is a cell-permeable, potent and selective p38 MAP kinase inhibitor that indirectly activates proteasome activity and has antiviral activity against Enterovirus71 with an IC50 value of 89 nM. |
| M2318 | Ralimetinib dimesylate | Ralimetinib dimesylate (LY2228820 dimesylate) is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM. |
| M2317 | VX-702 | VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM. |
| M2136 | PH-797804 | PH-797804 is a highly selective and potent inhibitor of p38 MAP kinase with IC50 of 26 nM. |
| M1556 | Hesperetin | Hesperetin is a potent and broad-spectrum inhibitor against human UGT activity. |
| M58462 | SSK1 | SSK1 is a senescence-specific killing compound and is a precursor for β-galactosidase, which can reduce the inflammatory response. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, promote mitochondrial DNA damage and selectively killed senescent cells. |
| M58461 | p38 MAP Kinase Inhibitor III | p38 MAP Kinase Inhibitor III is a p38 MAPK inhibitor with an IC50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with IC50 values of 0.37 μM and 0.044 μM, respectively. |
| M56443 | (R)-STU104 | (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. |
| M56442 | SB 706504 | SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD). |
| M56441 | RWJ-67657 | RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11 μM, respectively. |
| M54757 | BSJ-04-122 | BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively. |
| M54427 | OVA-E1 peptide TFA | OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). |
| M54176 | MBP MAPK Substrate | MBP MAPK Substrate is used as an exogenous substrate for MAPK. |
| M52814 | OVA-E1 peptide | OVA-E1 peptide, is an antagonist variant of SIINFEKL [OVA (257-264). |
| M52813 | EGF-R (661-681) T669 Peptide | EGF-R (661-681) T669 Peptide is a MAPK substrate that can used to measure MAPK catalytic activity. |
| M49726 | Anti-inflammatory agent 35 | Anti-inflammatory agent 35 is an orally active curcumin analogue with anti-inflammatory activity. |
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