| Cat.No. | Name | Information |
|---|---|---|
| M1781 | Adezmapimod (SB203580) | Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. |
| M2062 | SB 202190 | SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively. |
| M1675 | BIRB796 | BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK with Kd of 100pM. |
| M1556 | Hesperetin | Hesperetin is a potent and broad-spectrum inhibitor against human UGT activity. |
| M21038 | MK2 Inhibitor III | MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM. |
| M8991 | Dilmapimod | Dilmapimod (also known as SB-681323 and GW-681323) is a p38 MAPK inhibitor that potentially suppresses inflammation in COPD. |
| M3751 | Losmapimod | Losmapimod (GW856553) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. |
| M4474 | Cornuside | Cornuside is a terpene glycoside isolated from the fruit of Cornus officinalis Sieb. Et Zucc. Cornus officinalis is a traditional Oriental medicine that can be used to study inflammatory diseases and promote blood circulation. |
| M4415 | Sesamolin | Sesaminol can be isolated from Justicia Orbiculata and has antioxidant activity. Sesaminol inhibits lipid peroxidation and has neuroprotective effect. Sesaminol inhibits MAPK cascade by inhibiting phosphorylation of JNK, P38 MAPKs, and Caspase-3. |
| M3294 | VX-745 | VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ. |
| M3048 | TAK-715 | TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. |
| M3011 | Skepinone-L | Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM. |
| M2583 | PD 169316 | PD 169316 is a cell-permeable, potent and selective p38 MAP kinase inhibitor that indirectly activates proteasome activity and has antiviral activity against Enterovirus71 with an IC50 value of 89 nM. |
| M2318 | Ralimetinib dimesylate | Ralimetinib dimesylate (LY2228820 dimesylate) is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM. |
| M2317 | VX-702 | VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM. |
| M2136 | PH-797804 | PH-797804 is a highly selective and potent inhibitor of p38 MAP kinase with IC50 of 26 nM. |
| M58462 | SSK1 | SSK1 is a senescence-specific killing compound and is a precursor for β-galactosidase, which can reduce the inflammatory response. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, promote mitochondrial DNA damage and selectively killed senescent cells. |
| M58461 | p38 MAP Kinase Inhibitor III | p38 MAP Kinase Inhibitor III is a p38 MAPK inhibitor with an IC50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with IC50 values of 0.37 μM and 0.044 μM, respectively. |
| M56443 | (R)-STU104 | (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. |
| M56442 | SB 706504 | SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD). |
| M56441 | RWJ-67657 | RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11 μM, respectively. |
| M54757 | BSJ-04-122 | BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively. |
| M54427 | OVA-E1 peptide TFA | OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). |
| M54176 | MBP MAPK Substrate | MBP MAPK Substrate is used as an exogenous substrate for MAPK. |
| M52814 | OVA-E1 peptide | OVA-E1 peptide, is an antagonist variant of SIINFEKL [OVA (257-264). |
| M52813 | EGF-R (661-681) T669 Peptide | EGF-R (661-681) T669 Peptide is a MAPK substrate that can used to measure MAPK catalytic activity. |
| M49726 | Anti-inflammatory agent 35 | Anti-inflammatory agent 35 is an orally active curcumin analogue with anti-inflammatory activity. |
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