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Skepinone-L

Cat. No. M3011

All AbMole products are for research use only, cannot be used for human consumption.

Skepinone-L Structure
Synonym:

Skepinone L

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 145  USD145 In stock
25mg USD 290  USD290 In stock
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Quality Control & Documentation
Biological Activity

Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Mice
Formulation Methyl cellulose
Dosages ~3 mg/kg
Administration Oral administration
Chemical Information
Molecular Weight 425.42
Formula C24H21F2NO4
CAS Number 1221485-83-1
Solubility (25°C) DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Carmen Carrillo Garca, et al. High-Throughput Screening Platform in Postnatal Heart Cells and Chemical Probe Toolbox to Assess Cardiomyocyte Proliferation

[2] Philipp Guenthoer, et al. Evaluation of the therapeutic potential of the selective p38 MAPK inhibitor Skepinone-L and the dual p38/JNK 3 inhibitor LN 950 in experimental K/BxN serum transfer arthritis

[3] Fei Cheng, et al. Selective p38α MAP kinase/MAPK14 inhibition in enzymatically modified LDL-stimulated human monocytes: implications for atherosclerosis

[4] Oliver Borst, et al. Skepinone-L, a novel potent and highly selective inhibitor of p38 MAP kinase, effectively impairs platelet activation and thrombus formation

[5] Solveigh C Koeberle, et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor

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Keywords: Skepinone-L, Skepinone L supplier, p38 MAPK, inhibitors, activators

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