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MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM. MK2-IN-3 inhibits TNFα production in U937 cells, with IC50 of 4.4 μM, respectively. MK2-IN-3 (20 mg/kg; a single p.o. before LPS challenge) inhibits 20% TNFα production in rat LPS (rLPS) model.
| Molecular Weight | 340.38 |
| Formula | C21H16N4O |
| CAS Number | 724711-21-1 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | -20°C, protect from light |
| Related p38 MAPK Products |
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SSK1 is a senescence-specific killing compound and is a precursor for β-galactosidase, which can reduce the inflammatory response. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, promote mitochondrial DNA damage and selectively killed senescent cells. |
| p38 MAP Kinase Inhibitor III
p38 MAP Kinase Inhibitor III is a p38 MAPK inhibitor with an IC50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with IC50 values of 0.37 μM and 0.044 μM, respectively. |
| (R)-STU104
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| SB 706504
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| RWJ-67657
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