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SD-06

Cat. No. M7558
SD-06  Structure
Size Price Availability
5mg USD 450  USD450 4-7 Days
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Quality Control & Documentation
Biological Activity

SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). IC50 value: 170 nM Target: p38MAPK

Chemical Information
Molecular Weight 397.86
Formula C20H20ClN5O2
CAS Number 271576-80-8
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhu LQ, et al. Acta Virol. Identification of a bovine viral diarrhea virus 2 isolated from cattle in China.

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  Catalog
Abmole Inhibitor Catalog




Keywords: SD-06 supplier, p38 MAPK, inhibitors, activators


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