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GNE-3511

Cat. No. M14164

All AbMole products are for research use only, cannot be used for human consumption.

GNE-3511 Structure
Size Price Availability Quantity
10mg USD 90  USD90 In stock
25mg USD 150  USD150 In stock
50mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

GNE-3511 is an orally active, bioavailable and brain-permeable dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM.GNE-3511 can be used in studies related to neurodegenerative diseases.

Chemical Information
Molecular Weight 440.49
CAS Number 1496581-76-0
Solubility (25°C) DMSO 31.25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chen Jiang, et al. Neuronal Dual Leucine Zipper Kinase Mediates Inflammatory and Nociceptive Responses in Cyclophosphamide-Induced Cystitis

[2] Alexandra Russo, et al. Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome

[3] Snahel Patel, et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models

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Keywords: GNE-3511 supplier, p38 MAPK, inhibitors, activators

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